Evidence map›Paper›PMID 27938377›Full record

ArticleVirology journal2016

Rapid and sensitive point-of-care detection of Orthopoxviruses by ABICAP immunofiltration.

Daniel Stern, Victoria A Olson, Scott K Smith, Marko Pietraszczyk, Lilija Miller, Peter Miethe, Brigitte G Dorner, Andreas Nitsche

Abstract readEvaluation Study
In one paragraph

Article in Virology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Mpox disease, diagnosis, and point of care platforms.Bioengineering & translational medicine · 2025
    Review
  2. Review
  3. Role of the Laboratory in the Diagnosis of Poxvirus Infections.Advances in experimental medicine and biology · 2024
    Review
  4. Biological Characteristics and Pathogenesis of Monkeypox Virus: An Overview.Advances in experimental medicine and biology · 2024
    Review
  5. Review
  6. Review
  7. Monkeypox disease and pregnancy. Where are we today? A review of literature.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Current and Perspective Sensing Methods for Monkeypox Virus.Bioengineering (Basel, Switzerland) · 2022
    Review
  14. Enhanced surveillance of monkeypox in Bas-Uélé, Democratic Republic of Congo: the limitations of symptom-based case definitions.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  15. Review
  16. Article
  17. Review
  18. Poxvirus-driven human diseases and emerging therapeutics.Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel SternCentre for Biological Threats and Special Pathogens (ZBS), Robert Koch Institute, Seestrasse 10, 13353, Berlin, Germany. SternD@rki.de.ORCID 0000-0001-9057-4283
Victoria A OlsonDivision of High-Consequence Pathogens and Pathology, Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Scott K SmithDivision of High-Consequence Pathogens and Pathology, Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Marko PietraszczykSenova GmbH, Weimar, Germany.
Lilija MillerCentre for Biological Threats and Special Pathogens (ZBS), Robert Koch Institute, Seestrasse 10, 13353, Berlin, Germany.
Peter MietheFZMB GmbH, Bad Langensalza, Germany.
Brigitte G DornerCentre for Biological Threats and Special Pathogens (ZBS), Robert Koch Institute, Seestrasse 10, 13353, Berlin, Germany.
Andreas NitscheCentre for Biological Threats and Special Pathogens (ZBS), Robert Koch Institute, Seestrasse 10, 13353, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe rapid and reliable detection of infectious agents is one of the most challenging tasks in scenarios lacking well-equipped laboratory infrastructure, like diagnostics in rural areas of developing countries. Commercially available point-of-care diagnostic tests for emerging and rare diseases are particularly scarce.

resultsIn this work we present a point-of-care test for the detection of Orthopoxviruses (OPV). The OPV ABICAP assay detects down to 1 × 10

conclusionsGiven the high sensitivity and the ease of handling, the novel assay could be highly useful for on-site diagnostics of suspected Monkeypox virus infections in areas lacking proper laboratory infrastructure as well as rapid on-site testing of suspected bioterrorism samples.

Indexed as

Point-of-Care SystemsAnimalsFiltrationHumansImmunoassayOrthopoxvirusPoxviridae InfectionsSensitivity and SpecificityTime FactorsVirologyABICAPbioterrorismCowpox virusMonkeypox virusOrthopoxvirusPoint-of-careRapid detectionVaccinia virusVariola virusZoonosis

Identifiers

PMID27938377
PMCPMC5148848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.