ArticleBMC genomics2016
Genome sequence, population history, and pelage genetics of the endangered African wild dog (Lycaon pictus).
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- On the ancestry and evolution of the extinct dire wolf.Cell genomics · 2026Article
- Reduced Genetic Load and Inbreeding in Reintroduced African Wild Dogs Reflect the Benefits of Admixture.Molecular ecology · 2026Article
- Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus).Molecular ecology · 2025Article
- Haplotype-resolved genome and population genomics of the threatened garden dormouse in Europe.Genome research · 2024Article
- Prioritizing Endangered Species in Genome Sequencing: Conservation Genomics in Action with the First Platinum-Standard Reference-Quality Genome of the Critically Endangered European MinkInternational journal of molecular sciences · 2023Article
- Evidence, Challenges, and Knowledge Gaps Regarding Latent Tuberculosis in Animals.Microorganisms · 2022Review
- Ancient DNA from the Asiatic Wild Dog (Genes · 2021Article
- Genomes of Pleistocene Siberian Wolves Uncover Multiple Extinct Wolf Lineages.Current biology : CB · 2021Article
- Fifty Years of Research on European MinkGenes · 2020Review
- Comparative genomics provides new insights into the remarkable adaptations of the African wild dog (Lycaon pictus).Scientific reports · 2019Article
- Cost-effective assembly of the African wild dog (Lycaon pictus) genome using linked reads.GigaScience · 2019Article
- Article
- Interspecific Gene Flow Shaped the Evolution of the Genus Canis.Current biology : CB · 2018Article
- Genome sequence and population declines in the critically endangered greater bamboo lemur (Prolemur simus) and implications for conservation.BMC genomics · 2018Article
- The conservation physiology toolbox: status and opportunities.Conservation physiology · 2018Article
- Integrative Approaches for Studying Mitochondrial and Nuclear Genome Co-evolution in Oxidative Phosphorylation.Frontiers in genetics · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe African wild dog (Lycaon pictus) is an endangered African canid threatened by severe habitat fragmentation, human-wildlife conflict, and infectious disease. A highly specialized carnivore, it is distinguished by its social structure, dental morphology, absence of dewclaws, and colorful pelage.
resultsWe sequenced the genomes of two individuals from populations representing two distinct ecological histories (Laikipia County, Kenya and KwaZulu-Natal Province, South Africa). We reconstructed population demographic histories for the two individuals and scanned the genomes for evidence of selection.
conclusionsWe show that the African wild dog has undergone at least two effective population size reductions in the last 1,000,000 years. We found evidence of Lycaon individual-specific regions of low diversity, suggestive of inbreeding or population-specific selection. Further research is needed to clarify whether these population reductions and low diversity regions are characteristic of the species as a whole. We documented positive selection on the Lycaon mitochondrial genome. Finally, we identified several candidate genes (ASIP, MITF, MLPH, PMEL) that may play a role in the characteristic Lycaon pelage.
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