ArticleBMC medical genetics2016
A single nucleotide polymorphism in the UMOD promoter is associated with end stage renal disease.
Article in BMC medical genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Influence of inflammatory and reninangiotensin system gene polymorphisms ACE2 rs2285666, IL1A rs1800587, and TNF rs1800629 on COVID-19 severity and the persistence of symptoms in the post-COVID-19 phase: a cross-sectional study.Einstein (Sao Paulo, Brazil) · 2026Article
- BRG1 is involved in vascular calcification in chronic renal disease via autophagy of vascular smooth muscle cells.iScience · 2023Article
- Implementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance.Life (Basel, Switzerland) · 2020Article
- Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.Frontiers in genetics · 2019Review
- Uromodulin rs4293393 T>C variation is associated with kidney disease in patients with type 2 diabetes.The Indian journal of medical research · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral genome-wide association studies revealed that several variants of UMOD gene were related to the estimated glomerular filtration rate (eGFR), CKD or hypertension. In this study, we investigated the association between a common variant rs13333226 in the promoter region of UMOD gene and end stage renal disease (ESRD).
methodsVariant rs13333226 of UMOD gene was genotyped by using the ABI Real time TaqMan allelic discrimination assay in a case-control study including 638 unrelated patients with ESRD and 366 controls.
resultsThe frequency of UMOD SNP rs13333226 GG/GA genotype was significantly higher (36.83% vs. 20.22%, P = 4.02 × 10
conclusionsA common variation rs13333226 in the promoter region of UMOD gene was independently associated with ESRD in Han Chinese.
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