ArticlePharmaceutical biology2017
Gastroprotective activity of the resin from Virola oleifera.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
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- Development and Evaluation ofAntioxidants (Basel, Switzerland) · 2022Article
- Pharmacological Extracts and Molecules fromMolecules (Basel, Switzerland) · 2021Review
- Evaluation of Antiulcer Activity of Peltophorum Pterocarpum.Journal of clinical and diagnostic research : JCDR · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe resin from the trunk wood of Virola oleifera (Schott) A. C. Smith (Myristicaceae) is used in folk medicine to hasten wound repair and to treat pain and inflammatory conditions, and our previous report indicated the anti-oxidative properties in other oxidative stress model.
objectiveTo investigate the protective effects of resin from V. oleifera in two experimental models of gastric ulcer oxidative-stress dependent. MATERIALS AND
methodsPlant material was collected and the resin was subjected to partitioning with organic solvents. The buthanol fraction was subjected to chromatographic and spectrometric methods for isolation and structural elucidation. The resin was quantified for polyphenols and flavonoids by colorimetric methods. Furthermore, the antioxidant activity of resin was determined by three different methods. The ulcers were induced acutely in Swiss male mice with ethanol/HCl and indomethacin using single-doses of 10 and 100 mg/kg. The gastroprotection of the experimental groups was comparable to reference control lansoprazole (3 mg/kg).
resultsThe high content of polyphenols (∼82%) and the presence of epicatechin and eriodictyol were determined. The LD DISCUSSION: The gastroprotection might be related to tannins, phenolic acids and flavonoids present in the resin by antioxidant properties.
conclusionsThe results indicate that this resin has gastroprotective activity probably associated with the presence of phenolic antioxidant substances.
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Registered trials
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