Evidence map›Paper›PMID 27936809›Full record

ArticleBiointerphases2016

Provenance information as a tool for addressing engineered nanoparticle reproducibility challenges.

Donald R Baer, Prabhakaran Munusamy, Brian D Thrall

Abstract read
In one paragraph

Article in Biointerphases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Characterization of Nanoparticle Batch-To-Batch Variability.Nanomaterials (Basel, Switzerland) · 2018
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Donald R BaerEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352.
Prabhakaran MunusamyEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352.
Brian D ThrallEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352.

Funding

Project 3: Dosimetry and Structure-Activity Relationships for Nanomaterial Risk AU19ES019544 · NIEHS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI THRALL, BRIAN D. · 2010 to 2014
$6.0M
NIEHS NIH HHS U19 ES019544
6 · The paper itself

Abstract

Nanoparticles of various types are of increasing research and technological importance in biological and other applications. Difficulties in the production and delivery of nanoparticles with consistent and well defined properties appear in many forms and have a variety of causes. Among several issues are those associated with incomplete information about the history of particles involved in research studies, including the synthesis method, sample history after synthesis, including time and nature of storage, and the detailed nature of any sample processing or modification. In addition, the tendency of particles to change with time or environmental condition suggests that the time between analysis and application is important and some type of consistency or verification process can be important. The essential history of a set of particles can be identified as provenance information and tells the origin or source of a batch of nano-objects along with information related to handling and any changes that may have taken place since it was originated. A record of sample provenance information for a set of particles can play a useful role in identifying some of the sources and decreasing the extent of particle variability and the lack of reproducibility observed by many researchers.

Indexed as

Chemical PhenomenaBiomedical ResearchNanoparticlesReproducibility of Results

Identifiers

PMID27936809
PMCPMC5074995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.