Trial reportJournal of affective disorders2017
Exercise is an effective treatment for positive valence symptoms in major depression.
Trial report in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Exercise type and settings, quality of life, and mental health in coronary artery disease: a network meta-analysis.European heart journal · 2025Pooled it
- Effectiveness of physiotherapy techniques on depressive symptoms in older adults: a systematic review.Frontiers in public health · 2025Pooled it
- Physical activity and mental health: a systematic review and best-evidence synthesis of mediation and moderation studies.The international journal of behavioral nutrition and physical activity · 2024Pooled it
- Effects of Exercise Therapy on Anxiety and Depression in Patients With Coronary Heart Disease: A Meta-Analysis of a Randomized Controlled Study.Frontiers in cardiovascular medicine · 2021Pooled it
- "Caminando y socializando con Happy Older Latinos are Active (HOLA)": Results of a randomized clinical trial to promote health and prevent depression and anxiety in older Latinos.Journal of consulting and clinical psychology · 2025Trial
- Voluntary wheel running in male mice mitigates select hyperglycemia-induced depressive-like behaviors and modulates BDNF andBrain, behavior, & immunity - health · 2026Article
- Determinants of physical activity among Chinese college students: a COM-B and TDF-based qualitative study.BMC public health · 2026Article
- Effects of exercise supplementary to standard therapy on cognition and sleep in depression: a randomised controlled trial.Frontiers in psychiatry · 2026Article
- Anhedonia and PTSD symptom severity profiles differentially influence physical activity volume in trauma-exposed adults.European journal of psychotraumatology · 2025Article
- Improving Sleep Quality to Enhance Athletic Activity-The Role of Nutrition and Supplementation: A Mini-Short Review.Nutrients · 2025Review
- Therapeutic Guidelines for the Self-Management of Major Depressive Disorder: Scoping Review.Interactive journal of medical research · 2025Review
- The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach.BMC psychiatry · 2025Article
- The effects of exercise and rTMS on depression symptoms in adolescents depression.Frontiers in psychology · 2025Article
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- From movement to motivation: a proposed framework to understand the antidepressant effect of exercise.Translational psychiatry · 2024Review
- The influence of physical literacy of student with different obesity levels on physical fitness: the mediating effect of MVPA.Frontiers in public health · 2024Article
- Acute changes in affective valence and perceived distress predict reductions in PTSD symptom severity.Mental health and physical activity · 2023Article
- Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: a scoping review.Frontiers in human neuroscience · 2023Article
- Differential Associations Between Depressive Symptom-Domains With Anxiety, Loneliness, and Cognition in a Sample of Community Older Chinese Adults: A Multiple Indicators Multiple Causes Approach.Innovation in aging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionMeasurement of symptoms domains and their response to treatment in relative isolation from diagnosed mental disorders has gained new urgency, as reflected by the National Institute of Mental Health's introduction of the Research Domain Criteria (RDoC). The Snaith Hamilton Pleasure Scale (SHAPS) and the Motivation and Energy Inventory (MEI) are two scales measuring positive valence symptoms. We evaluated the effect of exercise on positive valence symptoms of Major Depressive Disorder (MDD).
methodsSubjects in the Treatment with Exercise Augmentation for Depression (TREAD) study completed self-reported SHAPS and MEI during 12 weeks of exercise augmentation for depression. We evaluated the effect of exercise on SHAPS and MEI scores, and whether the changes were related to overall MDD severity measured with the Quick Inventory of Depression Symptomatology (QIDS).
resultsSHAPS and MEI scores significantly improved with exercise. MEI score change had larger effect size and greater correlation with change in QIDS score. MEI also showed significant moderator and mediator effects of exercise in MDD. LIMITATIONS: Generalizability to other treatments is limited. This study lacked other bio-behavioral markers that would enhance understanding of the relationship of RDoC and the measures used.
conclusionsPositive valence symptoms improve with exercise treatment for depression, and this change correlates well with overall outcome. Motivation and energy may be more clinically relevant to outcome of exercise treatment than anhedonia.
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