Evidence map›Paper›PMID 27936223›Full record

ArticlePloS one2016

Central Obesity and H. pylori Infection Influence Risk of Barrett's Esophagus in an Asian Population.

Chih-Cheng Chen, Yao-Chun Hsu, Ching-Tai Lee, Chia-Chang Hsu, Chi-Ming Tai, Wen-Lun Wang, Cheng-Hao Tseng, Chao-Tien Hsu, Jaw-Town Lin, Chi-Yang Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Association of Barrett's esophagus withTherapeutic advances in chronic disease · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chih-Cheng ChenDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Yao-Chun HsuDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Ching-Tai LeeDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chia-Chang HsuDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chi-Ming TaiDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Wen-Lun WangDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Cheng-Hao TsengDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chao-Tien HsuDepartment of Pathology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Jaw-Town LinDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chi-Yang ChangDepartment of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.ORCID http://orcid.org/0000-0002-6936-5142
E-Da Hospital · TWFu Jen Catholic University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe prevalence rates of Barrett's esophagus (BE) in western countries are higher than Asian ones, but little is known about their difference among risk factors of BE. The aim of this study is to investigate the associations of various risk factors including central obesity, body mass index (BMI), metabolic syndrome and H. pylori infection, with BE.

methodsA total of 161 subjects with BE were enrolled and compared to age- and gender-matched controls randomly sampled (1:4) from check-up center in same hospital. Central obesity was defined by waist circumference (female>80cm; male>90cm), metabolic syndrome by the modified National Cholesterol Education Program Adult Treatment Panel III criteria in Taiwan. Independent risk factors for BE were identified by multiple logistic regression analyses.

resultsThe mean age for BE was 53.8±13.7 years and 75.8% was male. H. pylori infection status was detected by the rapid urease test with the prevalence of 28.4% and 44.4% in the BE patients and controls, respectively. The univariate logistic regression analyses showed the risk was associated with higher waist circumference (odds ratio [OR], 2.53; 95% confidence interval [CI], 1.78-3.60), metabolic syndrome (OR, 2.02; 95% CI, 1.38-2.96) and negative H. pylori infection (OR, 0.50; 95% CI, 0.34-0.74). However, multivariate logistic regression analyses revealed that BE associated with higher waist circumference (adjusted OR, 2.79; 95% CI, 1.89-4.12) and negative H. pylori infection (adjusted OR, 0.46; 95% CI, 0.30-0.70).

conclusionsCentral obesity is associated with a higher risk of BE whereas H. pylori infection with a lower risk in an ethnic Chinese population.

Indexed as

AdultAgedAsian PeopleBarrett EsophagusFemaleHelicobacter pyloriHumansMaleMiddle AgedObesity, Abdominal

Identifiers

PMID27936223
PMCPMC5148584
OpenAlexW2560003679

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.