Evidence map›Paper›PMID 27936214›Full record

Trial reportPloS one2016

Deep Neuromuscular Block Improves Surgical Conditions during Bariatric Surgery and Reduces Postoperative Pain: A Randomized Double Blind Controlled Trial.

Bart Torensma, Chris H Martini, Martijn Boon, Erik Olofsen, Bas In 't Veld, Ronald S L Liem, Mireille T T Knook, Dingeman J Swank, Albert Dahan

5 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03726372 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effect of Neuromuscular Blockade Protocol on Perioperative Outcomes of Robotic Laparoscopic Surgery

TypeinterventionalSponsorAir Force Military Medical University, ChinaRan2018 to 2019Enrolled192ConditionsGeneral Anesthesia, Postoperative ComplicationsArmsRocuronium, continuous infusion, intermittent injection
NCT04124757 nacompletednot on this mapstarted 2020, after this paper: background citation

The Impact of Deep Versus Standard Muscle Relaxation on Intra-operative Safety During Laparoscopic Surgery: a Multicenter Strategy Study

TypeinterventionalSponsorLeiden University Medical CenterRan2020 to 2024Enrolled731ConditionsNeuromuscular Blockade, Rocuronium, Anesthetics, Anesthesia ComplicationArmsDeep neuromuscular block
NCT04371588 completednot on this mapstarted 2018, after this paper: background citation

Effect of Perioperative Muscle Relaxant Model on Postoperative Outcomes in Chinese Patients

TypeobservationalSponsorAir Force Military Medical University, ChinaRan2018 to 2021Enrolled999ConditionsPostoperative ComplicationsArmsNo Response to Train of Four Stimulation, 1-2 Response to Train of Four Stimulation
NCT05689957 nacompletednot on this mapstarted 2020, after this paper: background citation

Evaluation of Surgical Condition During Laparoscopic Gynaecological Surgery in Patient With Moderate vs Deep Neuromuscular Block in Lower Pressure Pneumoperitoneum

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2020 to 2022Enrolled70ConditionsGynecologic Disease, Neuromuscular BlockadeArmsDeep neuromuscular block using intravenous rocuronium induction at 1.2mg/kg and maintainance of 8-12mcg/kg/min for deep neuromuscular block
NCT06517524 completednot on this mapstarted 2023, after this paper: background citation

Effects of Low-pressure Pneumoperitoneum Associated With Deep Pipecuronium-induced Neuromuscular Blockade on Hemodynamic Parameters for High Cardiovascular Risk Patient Undergoing General Anesthesia

TypeobservationalSponsorTamas Vegh, MDRan2023 to 2024Enrolled10ConditionsResidual Neuromuscular Block, Cardiovascular Diseases, Neuromuscular Blockade Monitoring
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bart TorensmaDepartment of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
Chris H MartiniDepartment of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
Martijn BoonDepartment of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
Erik OlofsenDepartment of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
Bas In 't VeldDepartment of Anesthesiology, Haaglanden Medical Center, The Hague, The Netherlands.
Ronald S L LiemDepartment of Surgery, Dutch Obesity Clinic West, The Hague, The Netherlands.
Mireille T T KnookDepartment of Surgery, Dutch Obesity Clinic West, The Hague, The Netherlands.
Dingeman J SwankDepartment of Surgery, Dutch Obesity Clinic West, The Hague, The Netherlands.
Albert DahanDepartment of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NLNederlandse Obesitas Kliniek · NLMedisch Centrum Haaglanden · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt remains unknown whether the administration of a deep neuromuscular block (NMB) during bariatric surgery improves surgical conditions and patient outcome. The authors studied the effect of deep versus moderate NMB in laparoscopic bariatric surgery on surgical conditions and postoperative pain. METHODS AND

resultsOne hundred patients scheduled to undergo elective bariatric surgery were randomized to a deep NMB (post-tetanic-count 2-3) or a moderate NMB (train-of-four 1-2). The quality of the surgical field was scored using the Leiden-Surgical Rating Scale (L-SRS), a 5-point scale ranging from 1 (extremely poor conditions) to 5 (optimal conditions). Three surgeons scored the L-SRS at 10-min intervals during surgery; postoperative pain scores were obtained in the postanesthesia-care-unit (PACU) and on the ward. Mean (95% confidence interval) L-SRS scores in moderate NMB 4.2 (4.0-4.4) versus 4.8 (4.7-4.9) in deep NMB (p < 0.001). Moderate NMB resulted in 17% of scores at L-SRS scores of 1-3, while deep NMB resulted in 100% scores at the high end of the L-SRS (4-5). Deep NMB led to improved pain scores in the PACU (4.6 (4.2-4.9) versus 3.9 (3.6-4.4), p = 0.03) and reduced shoulder pain on the ward (1.8 (1.5-2.1) versus 1.3 (1.1-1.5), p = 0.03). A composite score of pain and opioid use in the PACU favoured deep NMB (p = 0.001).

conclusionsIn bariatric surgery, deep relaxation has advantages for surgeon and patient. Compared to moderate NMB, deep NMB produced stable and improved surgical conditions with less postoperative pain.

Indexed as

Neuromuscular BlockadeAdultBariatric SurgeryDouble-Blind MethodFemaleHumansMaleMiddle AgedPostoperative Pain

Identifiers

PMID27936214
PMCPMC5148011
OpenAlexW2560031487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.