SynthesisPloS one2016
Risk Factors for Complications after Reduction Mammoplasty: A Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Risk factors for complications after reduction mammaplasty: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Does Prior Breast Irradiation Increase Complications of Subsequent Reduction Surgery in Breast Cancer Patients? A systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2024Pooled it
- Bilateral reduction mammaplasty with pulsed electron avalanche knife PlasmaBlade™ and conventional electrosurgical surgery: A retrospective, randomised controlled clinical trial.International wound journal · 2020Trial
- Assessment and AI-Based Prediction of Complications in Reduction Mammoplasty: A Combined Statistical and Fuzzy Inference Approach in a 10-Year Cohort from Tehran Hospitals (2013-2023).Aesthetic plastic surgery · 2026Article
- Off-Label Sildenafil Citrate as a Rescue Therapy for Areolar Venous Congestion Post-Breast Reduction: Case Series and Outcomes.Life (Basel, Switzerland) · 2025Article
- Factors Associated With Complications After Reduction Mammoplasty: Analysis of 5909 Patients Using a National Database: Facteurs associés aux complications après mammoplastie de réduction : analyse de 5909 cas de patientes à partir d'une base de données nationale.Plastic surgery (Oakville, Ont.) · 2025Article
- Gigantomastia: Advancing a Preference Score System to Enhance Care Quality and Life Standards.Aesthetic plastic surgery · 2025Article
- Nipple Sensation After Superomedial Breast Reduction: A Single Surgeon Study Evaluating Prognostic Factors.Plastic and reconstructive surgery. Global open · 2025Article
- Quality of Chest Masculinization in Trans Men: A Retrospective Study Evaluating Surgical Technique, Complications, Secondary Corrections, and Trends.Transgender health · 2025Article
- The Role of Tranexamic Acid Use in Reduction Mammaplasty: A Systematic Review and Meta-Analysis.Aesthetic surgery journal. Open forum · 2025Review
- BREAST-Q Analysis of Reduction Mammaplasty: Do Postoperative Complications of Breast Reduction Surgery Negatively Affect Patient Satisfaction?Aesthetic surgery journal · 2024Article
- Postoperative Complications Following Reduction Mammaplasty in Relation to Patient Body Mass Index.Eplasty · 2024Article
- Return to Work after Breast Reduction: A Comparative Study.Journal of clinical medicine · 2023Article
- Subdermal Plexus Density as It Relates to Obesity and Wound Complications in Patients Undergoing Reduction Mammaplasty.Eplasty · 2023Article
- Obesity and Complications in Mammoplasty: A Retrospective Review in an Obese Patient Population.Plastic and reconstructive surgery. Global open · 2022Article
- Gender-affirming Mastectomy: Comparison of Periareolar and Double Incision Patterns.Plastic and reconstructive surgery. Global open · 2022Article
- Predictive Patient Characteristics and Surgical Variables That Influence Postoperative Complications following Bilateral Reduction Mammoplasty.Plastic and reconstructive surgery. Global open · 2022Article
- Twenty Years of Breast Reduction Surgery at a Veterans Affairs Medical Center.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2021Article
- Natural course of fat necrosis after breast reconstruction: a 10-year follow-up study.BMC cancer · 2021Article
- The Impact of Metabolic Syndrome on Patients Undergoing Breast Reduction Surgery.Obesity surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReduction mammoplasty (RM) is a proven method of treating macromastia, but the risk factors for postoperative complications have not been clearly identified. Through this meta-analysis, the authors aimed to identify the risk factors of RM complications.
methodsAn extensive search of the literature describing complications after RM was performed using the PubMed Central, Embase, and Cochrane databases. The following risk factors were extracted: age, body mass index (BMI), tissue resection weight per breast (TRW), smoking and radiation therapy. Odds ratios (OR) were pooled with 95% confidence intervals (CI) to evaluate the relationship between these risk factors and complications after RM.
resultsA total of 16 unique studies including 10 593 patients were included in the final analysis. It showed that there was a significant difference in complications in BMI ≥30 kg/m2 (OR 0.73; 95% CI: 0.61-0.89, p = 0.001) and smoking (OR 1.56; 95% CI: 0.98-2.49, p = 0.06). Infection in those with BMI ≥30 kg/m2 showed a significant difference (OR 0.68; 95% CI: 0.52-0.89, p = 0.004), as well as wound dehiscence in smokers (OR 2.73; 95% CI: 1.60-4.67, p = 0.0002) and infection in irradiated breasts (OR 20.38; 95% CI: 3.42-121.35, p = 0.0009). However, there was no significant difference in age ≥50 years (OR 0.96; 95% CI: 0.71-1.29, p = 0.78), combined TRW ≥1000 g (OR 1.04; 95% CI: 0.43-2.50, p = 0.93).
conclusionsBMI ≥30 kg/m2 and smoking increase the risk of complications. Persons who are obese or irradiated are more likely to develop infections, and smokers experienced a higher incidence of wound dehiscence than did nonsmokers. However, patients aged ≥50 years and TRW ≥1000 g are not associated with complications from RM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.