ArticlePloS one2016
Diffusion-Based Design of Multi-Layered Ophthalmic Lenses for Controlled Drug Release.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- A Meta-Analysis of In Vitro Release of Hydrophilic Therapeutics from Contact Lenses Using Mathematical Modeling.Pharmaceutics · 2025Article
- Swelling Behavior, Biocompatibility, and Controlled Delivery of Sodium-Diclofenac in New Temperature-Responsive P(OEGMA/OPGMA) Copolymeric Hydrogels.Gels (Basel, Switzerland) · 2025Article
- Drug-Eluting Sandwich Hydrogel Lenses Based on Microchamber Film Drug Encapsulation.ACS nanoscience Au · 2023Article
- Engineering a drug eluting ocular patch for delivery and sustained release of anti-inflammatory therapeutics.AIChE journal. American Institute of Chemical Engineers · 2023Article
- Interpenetrating polymeric network (IPNs) in ophthalmic drug delivery: Breaking the barriers.International ophthalmology · 2023Review
- Therapeutic Contact Lenses with Polymeric Vehicles for Ocular Drug Delivery: A Review.Materials (Basel, Switzerland) · 2018Review
- Advancing Glaucoma Treatment through Materials Science: A Bibliometric Analysis.Journal of current ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of ocular drug delivery systems has been one of the most covered topics in drug delivery research. One potential drug carrier solution is the use of materials that are already commercially available in ophthalmic lenses for the correction of refractive errors. In this study, we present a diffusion-based mathematical model in which the parameters can be adjusted based on experimental results obtained under controlled conditions. The model allows for the design of multi-layered therapeutic ophthalmic lenses for controlled drug delivery. We show that the proper combination of materials with adequate drug diffusion coefficients, thicknesses and interfacial transport characteristics allows for the control of the delivery of drugs from multi-layered ophthalmic lenses, such that drug bursts can be minimized, and the release time can be maximized. As far as we know, this combination of a mathematical modelling approach with experimental validation of non-constant activity source lamellar structures, made of layers of different materials, accounting for the interface resistance to the drug diffusion, is a novel approach to the design of drug loaded multi-layered contact lenses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.