ArticlePloS one2016
Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Ashwagandha Root Extract Stabilises Physiological Stress Responses in Male and Female Team Sports Athletes During Pre-Season Training.Nutrients · 2026Trial
- Potential Adverse Effects of Ashwagandha: A Critical Review of Preclinical and Clinical Evidence.Phytotherapy research : PTR · 2026Review
- A Comparison of British and US Pharmacopoeia Standards for Quality of Ashwagandha Dietary Supplements in Commerce.Phytotherapy research : PTR · 2026Article
- The interplay of Ashwagandha with hormonal dynamics and gut microbiota in women with breast cancer: a tri-axial perspective.Journal of natural medicines · 2026Review
- Nutraceutical Applications ofFoods (Basel, Switzerland) · 2026Review
- Extraction of Bioactive Compounds FromInternational journal of food science · 2025Review
- Molecular Insights into the Inhibition of Lipid Accumulation in Hepatocytes by Unique Extracts of Ashwagandha.International journal of molecular sciences · 2024Article
- Review
- Article
- Liquid chromatography-mass spectrometry quantification of phytochemicals inFrontiers in chemistry · 2024Article
- Recent Advancements in Extraction Techniques of Ashwagandha (ACS omega · 2023Review
- Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury.International journal of environmental research and public health · 2023Article
- Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells.Journal of biomolecular structure & dynamics · 2022Article
- Effect of Ashwagandha Withanolides on Muscle Cell Differentiation.Biomolecules · 2021Article
- DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products ofCurrent research in toxicology · 2021Article
- Effects ofCurrent neuropharmacology · 2021Review
- Withanone fromDrug design, development and therapy · 2021Article
- Wild type p53 function in p53Journal of experimental & clinical cancer research : CR · 2019Article
- Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives.Frontiers in oncology · 2018Article
- Organic cultivation of Ashwagandha with improved biomass and high content of active Withanolides: Use of Vermicompost.PloS one · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ashwagandha (Withania somnifera) is an Ayurvedic herb commonly used in world-renowned traditional Indian home medicine system. Roots of Ashwagandha have been traditionally known to possess a variety of therapeutic and health promoting potentials that have not been sufficiently supported by laboratory studies. Nevertheless, most, if not all, of the preventive and therapeutic potentials have been assigned to its bioactive components, steroidal alkaloids and lactones. In contrast to the traditional use of roots, we have been exploring bioactivities in leaves of Ashwagandha. Here, we report that the leaves possess higher content of active Withanolides, Withaferin-A (Wi-A) and Withanone (Wi-N), as compared to the roots. We also established, for the first time, hydroponic cultivation of Ashwagandha and investigated the effect of various cultivation conditions on the content of Wi-A and Wi-N by chemical analysis and bioassays. We report that the Withanone/Withaferin A-rich leaves could be obtained by manipulating light condition during hydroponic cultivation. Furthermore, we recruited cyclodextrins to prepare extracts with desired ratio of Wi-N and Wi-A. Hydroponically grown Ashwagandha and its extracts with high ratio of withanolides are valuable for cancer treatment.
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