ArticlePLoS computational biology2016
Synchronization and Random Triggering of Lymphatic Vessel Contractions.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Numerical modeling of fluid exchange between a collecting lymphatic vessel and the surrounding tissue.Journal of mathematical biology · 2026Article
- Control of lymphatic pacemaking and pumping by mechanobiological signals.The Journal of physiology · 2025Article
- Lumped parameter simulations of cervical lymphatic vessels: dynamics of murine cerebrospinal fluid efflux from the skull.Fluids and barriers of the CNS · 2024Article
- Fluid dynamics and leukocyte transit in the lymphatic system.PNAS nexus · 2024Article
- A 1D model characterizing the role of spatiotemporal contraction distributions on lymph transport.Scientific reports · 2023Article
- Transport Barriers Influence the Activation of Anti-Tumor Immunity: A Systems Biology Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Article
- The effects of gravity and compression on interstitial fluid transport in the lower limb.Scientific reports · 2022Article
- A multiscale sliding filament model of lymphatic muscle pumping.Biomechanics and modeling in mechanobiology · 2021Article
- Off-Target Effect of Lovastatin Disrupts Dietary Lipid Uptake and Dissemination through Pro-Drug Inhibition of the Mesenteric Lymphatic Smooth Muscle Cell Contractile Apparatus.International journal of molecular sciences · 2021Article
- Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Fluid pumping of peristaltic vessel fitted with elastic valves.Journal of fluid mechanics · 2021Article
- Characterization of rat tail lymphatic contractility and biomechanics: incorporating nitric oxide-mediated vasoregulation.Journal of the Royal Society, Interface · 2020Article
- The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations.Scientific reports · 2019Article
- Entrainment of Lymphatic Contraction to Oscillatory Flow.Scientific reports · 2019Article
- Contraction of collecting lymphatics: organization of pressure-dependent rate for multiple lymphangions.Biomechanics and modeling in mechanobiology · 2018Article
- Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography.Journal of biophotonics · 2018Article
- Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.Trends in cancer · 2018Review
- Lymphatic function measurements influenced by contrast agent volume and body position.JCI insight · 2018Article
- Lymphatic System Flows.Annual review of fluid mechanics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The lymphatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike the cardiovascular system, lacks a centralized pump-the heart-to drive flow. Instead, each collecting lymphatic vessel can individually contract and dilate producing unidirectional flow enforced by intraluminal check valves. Due to the large number and spatial distribution of such pumps, high-level coordination would be unwieldy. This leads to the question of how each segment of lymphatic vessel responds to local signals that can contribute to the coordination of pumping on a network basis. Beginning with elementary fluid mechanics and known cellular behaviors, we show that two complementary oscillators emerge from i) mechanical stretch with calcium ion transport and ii) fluid shear stress induced nitric oxide production (NO). Using numerical simulation and linear stability analysis we show that the newly identified shear-NO oscillator shares similarities with the well-known Van der Pol oscillator, but has unique characteristics. Depending on the operating conditions, the shear-NO process may i) be inherently stable, ii) oscillate spontaneously in response to random disturbances or iii) synchronize with weak periodic stimuli. When the complementary shear-driven and stretch-driven oscillators interact, either may dominate, producing a rich family of behaviors similar to those observed in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.