ReviewReviews on environmental health2017
Environmental PAH exposure and male idiopathic infertility: a review on early life exposures and adult diagnosis.
Review in Reviews on environmental health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between exposure to polycyclic aromatic hydrocarbons and reproductive health outcomes: a systematic review and meta-analysis.Journal of health, population, and nutrition · 2025Pooled it
- Industrial Hydrocarbons Exposure Deteriorates Sperm Integrity and Reproductive Function.Journal of biochemical and molecular toxicology · 2026Article
- Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population.Journal of exposure science & environmental epidemiology · 2026Article
- Green treatments for polyaromatic hydrocarbons in e-wastes.Biodegradation · 2025Review
- One-Year Impact of Occupational Exposure to Polycyclic Aromatic Hydrocarbons on Sperm Quality.Antioxidants (Basel, Switzerland) · 2024Article
- The role of DNA methylation on gene expression in the vertebrae of ancestrally benzo[a]pyrene exposed F1 and F3 male medaka.Epigenetics · 2023Article
- Lifestyle and environmental risk factors for unexplained male infertility: study protocol for Australian Male Infertility Exposure (AMIE), a case-control study.Reproductive health · 2023Article
- Urinary polycyclic aromatic hydrocarbon metabolites are positively related to serum testosterone levels of males and serum estradiol levels of females among U.S. adults.Frontiers in endocrinology · 2022Article
- The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function.Current research in toxicology · 2022Article
- Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress.Environment international · 2021Article
- Benzo[a]pyrene and Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced locomotor and reproductive senescence and altered biochemical parameters of oxidative damage in Canton-SToxicology reports · 2021Article
- Interaction effect of polycyclic aromatic hydrocarbon metabolites and cadmium on semen quality in nonsmokers.Environmental science and pollution research international · 2020Article
- Sperm DNA Methylation Epimutation Biomarkers for Male Infertility and FSH Therapeutic Responsiveness.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The male reproductive system is acutely and uniquely sensitive to a variety of toxicities, including those induced by environmental pollutants throughout the lifespan. Early life hormonal and morphological development results in several especially sensitive critical windows of toxicity risk associated with lifelong decreased reproductive health and fitness. Male factor infertility can account for over 40% of infertility in couples seeking treatment, and 44% of infertile men are diagnosed with idiopathic male infertility. Human environmental exposures are poorly understood due to limited available data. The latency between maternal and in utero exposure and a diagnosis in adulthood complicates the correlation between environmental exposures and infertility. The results from this review include recommendations for more and region specific monitoring of polycyclic aromatic hydrocarbon (PAH) exposure, longitudinal and clinical cohort considerations of exposure normalization, gene-environment interactions, in utero exposure studies, and controlled mechanistic animal experiments. Additionally, it is recommended that detailed semen analysis and male fertility data be included as endpoints in environmental exposure cohort studies due to the sensitivity of the male reproductive system to environmental pollutants, including PAHs.
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Registered trials
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