Evidence map›Paper›PMID 27935844›Full record

ArticlemBio2016

Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome.

Mahmoud Ghannoum

Abstract readComment
In one paragraph

Article in mBio, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Symbiosis and Dysbiosis of the Human Mycobiome.Frontiers in microbiology · 2021
    Review
  9. Influence of gut microbiome on multiple myeloma: friend or foe?Journal for immunotherapy of cancer · 2020
    Article
  10. Review
  11. Mycobiome in the Gut: A Multiperspective Review.Mediators of inflammation · 2020
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. The mycobiome in HIV.Current opinion in HIV and AIDS · 2018
    Review
  17. Article
  18. A Summary of the Second Annual HIV Microbiome Workshop.AIDS research and human retroviruses · 2017
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Mahmoud GhannoumCenter for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA Mahmoud.Ghannoum@case.edu.

Funding

The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Theresa Torres Pizarro · 2015 to 2026
$15.6M
Mechanism of antifungal action of Pichia proteinsR01DE024228 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI GHANNOUM, MAHMOUD A · 2014 to 2018
$2.0M
Low-Dose High-Resolution Dental RadiographyR44DE017846 · NIDCR · DXRAY, INC. · PI HARTSOUGH, NEAL EUGENE · 2010 to 2011
$1.1M
Low-Dose High-Resolution Dental RadiographyR43DE017846 · NIDCR · DXRAY, INC. · PI HARTSOUGH, NEAL EUGENE · 2007 to 2007
$198k
NIDCR NIH HHS R01 DE024228NIDCR NIH HHS R43 DE017846NIDCR NIH HHS R44 DE017846NIDDK NIH HHS P30 DK097948
6 · The paper itself

Abstract

Nonhealing chronic wounds are all unique in origin and circumstance, and attempting to isolate a single etiology for the failure of a wound to heal is daunting. Wounds represent complex systems of multispecies fungal and bacterial biofilms. The survival strategies of interactive microbial communities have led to cooperative evolutionary strategies that culminate in biofilm formation. In microbial dysbiosis, biofilms are beneficial to both bacterial and fungal communities but detrimental to the host. Fungi benefit by a surge in their virulence factors, while bacteria become tolerant to antibacterials as a consequence of living under the protective umbrella of the biofilm matrix. This interkingdom cooperation negatively impacts the host, as the fungi and bacteria produce extracellular enzymes that inflict tissue damage, leading to an increase in proinflammatory cytokines, which results in oxidative damage and apoptotic cell death.

Indexed as

BiofilmsMycobiomeBacteriaDysbiosisFungi

Identifiers

PMID27935844
PMCPMC5111414

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.