ReviewDisease models & mechanisms2016
Renal disease pathophysiology and treatment: contributions from the rat.
Review in Disease models & mechanisms, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Impact of Micro-RNAs as biomarkers for end-stage renal disease related to hypertension and diabetes.Scientific reports · 2025Article
- Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression.Molecular systems biology · 2025Article
- Effects of Antioxidant Combinations on the Renal Toxicity Induced Rats by Gold Nanoparticles.Molecules (Basel, Switzerland) · 2023Article
- Molecular Mechanisms of Acute Organophosphate Nephrotoxicity.International journal of molecular sciences · 2022Review
- Multisystem involvement, defective lysosomes and impaired autophagy in a novel rat model of nephropathic cystinosis.Human molecular genetics · 2022Article
- Selecting the right therapeutic target for kidney disease.Frontiers in pharmacology · 2022Review
- L-NAME Administration Enhances Diabetic Kidney Disease Development in an STZ/NAD Rat Model.International journal of molecular sciences · 2021Article
- Creation of X-linked Alport syndrome rat model with Col4a5 deficiency.Scientific reports · 2021Article
- Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2.Kidney international reports · 2021Review
- Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage.American journal of nephrology · 2021Article
- Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway.BMC complementary medicine and therapies · 2020Article
- Serum metabolomics approach to monitor the changes in metabolite profiles following renal transplantation.Scientific reports · 2020Article
- MicroRNAs in Chronic Kidney Disease: Four Candidates for Clinical Application.International journal of molecular sciences · 2020Review
- Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats.Food science & nutrition · 2020Article
- Calcitriol Ameliorates Kidney Injury Through Reducing Podocytopathy, Tubular Injury, Inflammation and Fibrosis in 5/6 Subtotal Nephrectomy Model in Rats.The Kobe journal of medical sciences · 2020Article
- Successful production of genome-edited rats by the rGONAD method.BMC biotechnology · 2018Article
- Regulation, signalling and functions of hormonal peptides in pulmonary vascular remodelling during hypoxia.Endocrine · 2018Review
- Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model-comparative study.The EPMA journal · 2017Article
- Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla.BMC nephrology · 2017Article
- Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury.EBioMedicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments in genome engineering now allow us to capitalize on the wealth of knowledge acquired over the last century. Here, we review rat models of hypertension, diabetic nephropathy, and acute and chronic kidney disease. These models have made important contributions to our understanding of renal diseases and have revealed key genes, such as Ace and P2rx7, involved in renal pathogenic processes. By targeting these genes of interest, researchers are gaining a better understanding of the etiology of renal pathologies, with the promised potential of slowing disease progression or even reversing the damage caused. Some, but not all, of these target genes have proved to be of clinical relevance. However, it is now possible to generate more sophisticated and appropriate disease models in the rat, which can recapitulate key aspects of human renal pathology. These advances will ultimately be used to identify new treatments and therapeutic targets of much greater clinical relevance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.