Evidence map›Paper›PMID 27935639›Full record

ArticleImmunology2017

Peroxisome proliferator-activated receptor-β/δ modulates mast cell phenotype.

Pei-Li Yao, Jose L Morales, Frank J Gonzalez, Jeffrey M Peters

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pei-Li YaoDepartment of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA.
Jose L MoralesDepartment of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA.
Frank J GonzalezLaboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Jeffrey M PetersDepartment of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA.
Pennsylvania State University · USNational Cancer Institute · US

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
Xenobiotic ReceptorsZIABC005708 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$16.4M
Modulation of skin cancer by PPARBeta/deltaR01CA124533 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PETERS, JEFFREY M · 2007 to 2017
$2.4M
Transcriptional regulation of polycyclic aromatic hydrocarbon metabolismR01CA141029 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PETERS, JEFFREY M · 2010 to 2013
$1.1M
Liver-Enriched Transcription FactorsZIABC005561 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2010
$500k
Intramural NIH HHS ZIA BC005561Intramural NIH HHS ZIA BC005562Intramural NIH HHS ZIA BC005708NCI NIH HHS R01 CA124533NCI NIH HHS R01 CA141029
6 · The paper itself

Abstract

The peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is known to have multiple anti-inflammatory effects, typically observed in endothelial cells, macrophages, T cells and B cells. Despite the fact that mast cells are important mediators of inflammation, to date, the role of PPARβ/δ in mast cells has not been examined. Hence, the present study examined the hypothesis that PPARβ/δ modulates mast cell phenotype. Bone-marrow-derived mast cells (BMMCs) and peritoneal mast cells from Pparβ/δ

Indexed as

Cell DifferentiationAnimalsBone Marrow CellsCells, CulturedCytokinesExtracellular Signal-Regulated MAP KinasesFemaleInflammation MediatorsMast CellsMiceMice, Inbred C57BLMice, KnockoutPhenotypePPAR-betaPPAR deltaReceptors, IgECytokinesExtracellular Signal-Regulated MAP KinasesInflammation MediatorsPPAR-betaPPAR deltaReceptors, IgEbone marrow-derived mast cellscytokineinflammationperoxisome proliferator-activated receptor-β/δ

Identifiers

PMID27935639
PMCPMC5343360
OpenAlexW2559795365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.