ArticleACS applied materials & interfaces2017
Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors.
Article in ACS applied materials & interfaces, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- [Advances in application of cell imprinting technology in biomedical field].Se pu = Chinese journal of chromatography · 2026Review
- Imprinting of nanoparticles in thin films: Quo Vadis?Chemical science · 2023Review
- Preservation of Proteins in Human Plasma through Metal-Organic Framework Encapsulation.ACS applied materials & interfaces · 2023Article
- Specific determination of HBV using a viral aptamer molecular imprinting polymer sensor based on ratiometric metal organic framework.Mikrochimica acta · 2021Article
- Refreshable Nanobiosensor Based on Organosilica Encapsulation of Biorecognition Elements.ACS applied materials & interfaces · 2020Article
- PEGylation of protein-imprinted nanocomposites sandwiching CdTe quantum dots with enhanced fluorescence sensing selectivity.RSC advances · 2019Article
- Molecular Fingerprints of Hemoglobin on a Nanofilm Chip.Sensors (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Natural antibodies used as biorecognition elements suffer from numerous shortcomings, such as limited chemical and environmental stability and cost. Artificial antibodies based on molecular imprinting are an attractive alternative to natural antibodies. We investigated the role of aromatic interactions in target recognition capabilities of artificial antibodies. Three proteins with different aromatic amino acid content were employed as model targets. Artificial antibodies were formed on nanostructures using combinations of silane monomers of varying aromatic functionality. We employed refractive index sensitivity of plasmonic nanostructures as a transduction platform for monitoring various steps in the imprinting process and to quantify the target recognition capabilities of the artificial antibodies. The sensitivity of the artificial antibodies with aromatic interactions exhibited a protein-dependent enhancement. Selectivity and sensitivity enhancement due to the presence of aromatic groups in imprinted polymer matrix was found to be higher for target proteins with higher aromatic amino acid content. Our results indicate that tailoring the monomer composition based on the amino acid content of the target protein can improve the sensitivity of plasmonic biosensors based on artificial antibodies without affecting the selectivity.
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Registered trials
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