Evidence map›Paper›PMID 2793524›Full record

ArticleThe Histochemical journal1989

An immunological study on chromogranin A and B in human endocrine and nervous tissues.

K W Schmid, R Weiler, R W Xu, R Hogue-Angeletti, R Fischer-Colbrie, H Winkler

Abstract read
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In one paragraph

Article in The Histochemical journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

K W SchmidDepartment of Pathology, University of Innsbruck, Austria.
R Weiler
R W Xu
R Hogue-Angeletti
R Fischer-Colbrie
H Winkler
Universität Innsbruck · ATUniversity of Pennsylvania · US

Funding

CHROMOGRANIN &THE NEUROENDOCRINE SYSTEMR01NS022697 · NINDS · YESHIVA UNIVERSITY · PI ANGELETTI, RUTH HOGUE · 1986 to 1995
–
CHROMOGRANIN &THE NEUROENDOCRINE SYSTEMR55NS022697 · NINDS · YESHIVA UNIVERSITY · PI ANGELETTI, RUTH HOGUE · 1991 to 1991
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NINDS NIH HHS NS 22697
6 · The paper itself

Abstract

Antisera were raised against synthetic peptides derived from the primary amino acid sequence of human chromogranin B. These antisera recognized in one- and two-dimensional immunoblotting a component previously designated as chromogranin B. In human chromaffin granules, the major endogenous processing product of chromogranin B is formed by proteolytic cleavage of the protein near the C-terminus. Immunohistochemical localizations were obtained with antisera against human chromogranins A and B and against a synthetic peptide corresponding to the B sequence. In human tissues, chromogranin B is co-stored with chromogranin A in the adrenal medulla, the anterior pituitary, parafollicular cells of the thyroid, in some cells of the endocrine pancreas and in some enterochromaffin cells, whereas only chromogranin A is found in the parathyroid gland and enterochromaffin cells of the gastric corpus mucosa. In the nervous system, no immunostaining was observed for chromogranin A and only a weak one for chromogranin B in some cells of the spinal cord. However, the Purkinje cells of the cerebellum were strongly positive for chromogranin B.

Indexed as

Chromogranin AChromograninsEndocrine GlandsHumansImmune SeraImmunoblottingImmunohistochemistryNerve TissueNerve Tissue ProteinsCHGA protein, humanChromogranin AChromograninsImmune SeraNerve Tissue Proteins

Identifiers

PMID2793524
OpenAlexW2018177769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.