Evidence map›Paper›PMID 27935079›Full record

ArticleMuscle & nerve2017

High-resolution manometry in patients with idiopathic inflammatory myopathy: Elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset.

Maria Casal-Dominguez, Iago Pinal-Fernandez, Marianela Mego, Anna Accarino, Lluis Jubany, Fernando Azpiroz, Albert Selva-O'callaghan

Abstract read
In one paragraph

Article in Muscle & nerve, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Defining anti-synthetase syndrome: a systematic literature review.Clinical and experimental rheumatology · 2022
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Esophageal Manifestations of Dermatological Diseases, Diagnosis and Management.Current treatment options in gastroenterology · 2022
    Article
  9. Review
  10. Idiopathic inflammatory myopathies.Nature reviews. Disease primers · 2021
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Bench to bedside review of myositis autoantibodies.Clinical and molecular allergy : CMA · 2018
    Review
  16. Dysphagia as the Presenting Symptom for Inclusion Body Myositis.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria Casal-DominguezDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Iago Pinal-FernandezAutoimmune Systemic Diseases Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.ORCID 0000-0001-6338-9218
Marianela MegoCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd). Digestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Anna AccarinoCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd). Digestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Lluis JubanyAutoimmune Systemic Diseases Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
Fernando AzpirozCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd). Digestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Albert Selva-O'callaghanAutoimmune Systemic Diseases Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.

Funding

Intramural NIH HHS Z99 AR999999
6 · The paper itself

Abstract

introductionIn this study we assessed high-resolution manometry (HRM) findings in patients with dermatomyositis and polymyositis.

methodsFrom 2008 to 2015, we performed a cross-sectional study of myositis patients. A survey of esophageal symptoms and HRM data were analyzed and compared among different clinical and serologic groups.

resultsTwenty-four (45%) of the 53 patients included in the study had manometric involvement that was not correlated with any esophageal symptom (P = 0.8). Failed waves (34% vs. 0%, P = 0.004) and decreased upper esophageal sphincter pressure (50 vs. 70 mm Hg, P = 0.03) were more common in polymyositis than in dermatomyositis patients. Jackhammer esophagus was more common in anti-TIF1-γ patients (30% vs. 9%, P = 0.04), and lower esophageal sphincter involvement (47% vs. 25%, P = 0.03) was more prevalent in patients with the antisynthetase syndrome.

conclusionsEsophageal involvement is common in myositis patients, but it correlates poorly with esophageal symptoms. Specific clinical and serologic groups have different manometric features. Muscle Nerve 56: 386-392, 2017.

Indexed as

AdultAgedAged, 80 and overAutoantibodiesCross-Sectional StudiesEsophageal Motility DisordersEsophageal Sphincter, LowerEsophagusFemaleHumansMaleManometryMiddle AgedMyositisPrevalenceAutoantibodiesautoantibodiesdermatomyositisdysphagiaesophageal involvementhigh-resolution manometrypolymyositis

Identifiers

PMID27935079
PMCPMC11669103

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.