Evidence map›Paper›PMID 27935058›Full record

ArticlePhotochemistry and photobiology2017

Bimodal Targeting Using Sulfonated, Mannosylated PEI for Combined Gene Delivery and Photodynamic Therapy.

Upendra Chitgupi, Yi Li, Mingfu Chen, Shuai Shao, Marie Beitelshees, Myles Joshua Tan, Sriram Neelamegham, Blaine A Pfeifer, Charles Jones, Jonathan F Lovell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemistry and photobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Upendra ChitgupiDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY.
Yi LiDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY.
Mingfu ChenDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY.ORCID 0000-0002-0169-613X
Shuai ShaoDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY.
Marie BeitelsheesDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY.
Myles Joshua TanDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY.
Sriram NeelameghamDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY.
Blaine A PfeiferDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, NY.
Charles JonesAbcombi Biosciences Inc., Buffalo, NY.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY.
University at Buffalo, State University of New York · USAbcombi Biosciences (United States) · US

Funding

Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
A Hybrid Bio-synthetic Vector Designed to Elicit Directed in vivo Immune ResponseR21AI117309 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PFEIFER, BLAINE A. · 2016 to 2017
$435k
NIAID NIH HHS R21 AI117309NIH HHS DP5 OD017898
6 · The paper itself

Abstract

Photodynamic therapy (PDT) and gene delivery have both been used to target both cancer cells and tumor-associated macrophages (TAMs). Given the complex nature of tumor tissue, there could be merit in combining these strategies simultaneously. In this study, we developed a bimodal targeting approach to both cancer cells and macrophages, employing materials conducive to both gene delivery and PDT. Polymers libraries were created that consisted of cationic polyethyleneimine (PEI) conjugated to the photosensitizer pyropheophorbide-a, with sulfonation (to target selectin-expressing cells) and mannosylation (to target TAMs). Polyplexes, consisting of these polymers electrostatically bound to DNA, were analyzed for transfection efficacy and cytotoxicity toward epithelial cells and macrophages to assess dual-targeting. This study provides preliminary proof of principle for using modified PEI for targeted gene delivery and PDT.

Indexed as

PhotochemotherapyTransfectionAnimalsCHO CellsCricetulusDNAEpithelial CellsLuminescenceMacrophagesMannoseMosaic VirusesPolyethyleneimineStatic ElectricitySulfonesDNAMannosePolyethyleneimineSulfones

Identifiers

PMID27935058
PMCPMC6230323
OpenAlexW2560508564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.