Evidence map›Paper›PMID 27934948›Full record

ArticleScientific reports2016

Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma.

Yi-Hsin Tseng, Ya-Hui Huang, Tzu-Kang Lin, Sheng-Ming Wu, Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Wei-Chun Chang, Ya-Ting Chang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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  11. Anticancer Effects ofJournal of Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Yi-Hsin TsengGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Ya-Hui HuangLiver Research Center, Chang Gung Memorial Hospital, Linko, Taoyuan 333, Taiwan, Republic of China.
Tzu-Kang LinDivision of Neurosurgery, Chang Gung Memorial Hospital-Linkou &Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Sheng-Ming WuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Hsiang-Cheng ChiGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Chung-Ying TsaiGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Ming-Ming TsaiDepartment of Nursing, Chang-Gung University of Science and Technology, Taoyuan 333, Taiwan, Republic of China.
Yang-Hsiang LinGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Wei-Chun ChangGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Ya-Ting ChangMolecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Wei-Jan ChenFirst Cardiovascular Division, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan, Republic of China.
Kwang-Huei LinGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, Republic of China.
Chang Gung University · TWChang Gung Memorial Hospital · TWChang Gung University of Science and Technology · TWLinkou Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stathmin (STMN1), a recognized oncoprotein upregulated in various solid tumors, promotes microtubule disassembly and modulates tumor growth and migration activity. However, the mechanisms underlying the genetic regulation of STMN1 have yet to be elucidated. In the current study, we report that thyroid hormone receptor (THR) expression is negatively correlated with STMN1 expression in a subset of clinical hepatocellular carcinoma (HCC) specimens. We further identified the STMN1 gene as a target of thyroid hormone (T

Indexed as

Carcinoma, HepatocellularCell DivisionGene Knockdown TechniquesHep G2 CellsHumansLiver NeoplasmsReceptors, Thyroid HormoneStathminTriiodothyronineReceptors, Thyroid HormoneStathminSTMN1 protein, humanTriiodothyronine

Identifiers

PMID27934948
PMCPMC5146664
OpenAlexW2560032660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.