Evidence map›Paper›PMID 27934762›Full record

ArticleScience (New York, N.Y.)2016

Reactivation of latent working memories with transcranial magnetic stimulation.

Nathan S Rose, Joshua J LaRocque, Adam C Riggall, Olivia Gosseries, Michael J Starrett, Emma E Meyering, Bradley R Postle

Registry-linked trialAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06276400 (Lateral Prefrontal Organization in Emotion), which is not on this map. Cited by 253 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06276400 narecruitingnot on this mapstarted 2024, after this paper: background citation

Lateral Prefrontal Organization in Emotion: Representational and Causal Mechanism - Duration Difference Estimation

TypeinterventionalSponsorUniversity of California, Santa BarbaraRan2024 to 2028Enrolled50ConditionsHealthyArmsEmotion valence, Time, TMS Stimulation
3 · Its place in the literature

Who cites it

253 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  16. Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  17. Selective removal of visual working memory items at test.bioRxiv : the preprint server for biology · 2026
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193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nathan S RoseDepartment of Psychiatry, University of Wisconsin, Madison, WI 53706, USA. nrose1@nd.edu postle@wisc.edu.
Joshua J LaRocqueDepartment of Psychiatry, University of Wisconsin, Madison, WI 53706, USA.
Adam C RiggallDepartment of Psychiatry, University of Wisconsin, Madison, WI 53706, USA.
Olivia GosseriesDepartment of Psychiatry, University of Wisconsin, Madison, WI 53706, USA.
Michael J StarrettDepartment of Psychiatry, University of Wisconsin, Madison, WI 53706, USA.
Emma E MeyeringDepartment of Psychiatry, University of Wisconsin, Madison, WI 53706, USA.
Bradley R PostleDepartment of Psychiatry, University of Wisconsin, Madison, WI 53706, USA. nrose1@nd.edu postle@wisc.edu.

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Oscillatory Contributions to Working Memory and AttentionR01MH095984 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI POSTLE, BRADLEY R · 2013 to 2023
$4.8M
NIGMS NIH HHS T32 GM008692NIMH NIH HHS R01 MH095984
6 · The paper itself

Abstract

The ability to hold information in working memory is fundamental for cognition. Contrary to the long-standing view that working memory depends on sustained, elevated activity, we present evidence suggesting that humans can hold information in working memory via "activity-silent" synaptic mechanisms. Using multivariate pattern analyses to decode brain activity patterns, we found that the active representation of an item in working memory drops to baseline when attention shifts away. A targeted pulse of transcranial magnetic stimulation produced a brief reemergence of the item in concurrently measured brain activity. This reactivation effect occurred and influenced memory performance only when the item was potentially relevant later in the trial, which suggests that the representation is dynamic and modifiable via cognitive control. The results support a synaptic theory of working memory.

Indexed as

Transcranial Magnetic StimulationAdolescentAdultAttentionBrainCognitionFemaleHumansMaleMemory, Short-TermNeuronal PlasticitySynapsesYoung Adult

Identifiers

PMID27934762
PMCPMC5221753

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.