ArticleGenome research2016
The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences.
Article in Genome research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed.
- A curated genome-scale nucleotide diversity panel of non-human primates.Genome biology · 2026Article
- Inferring the demographic history of Chinese and Indian rhesus macaque (Macaca mulatta) populations from PacBio HiFi long-read sequencing data.Molecular biology and evolution · 2026Article
- Sex-Specific Landscapes of Crossover and Noncrossover Recombination in Coppery Titi Monkeys (Plecturocebus cupreus).Genome biology and evolution · 2026Article
- Comparing the genomic inbreeding of an isolated rhesus macaque study population to wild populations.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide copy number variation drives adaptive evolution inCurrent zoology · 2026Article
- Recent Insights Into the Evolutionary Genomics of the Critically Endangered Aye-Aye (Daubentonia madagascariensis).American journal of primatology · 2025Review
- Two novel species-specific mitochondrial markers for non-invasive identification of rhesus macaques (Macaca mulatta).Molecular biology reports · 2025Article
- Long-read structural variant discovery and targeted short read genotyping enables population scale characterization of structural variation in rhesus macaques.Genome biology · 2025Article
- Re-Evaluating the Demographic History of, and Inferring the Fine-Scale Recombination Landscape For, Wild Chinese Rhesus Macaques (Macaca mulatta).American journal of primatology · 2025Article
- Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort.Nature communications · 2025Article
- Article
- Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque.Molecular ecology · 2025Article
- Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection.The Lancet. Microbe · 2025Review
- A Pedigree-Based Map of Crossovers and Noncrossovers in Aye-Ayes (Daubentonia madagascariensis).Genome biology and evolution · 2025Article
- Article
- Population Genomics of Japanese Macaques (Macaca fuscata): Insights Into Deep Population Divergence and Multiple Merging Histories.Genome biology and evolution · 2025Article
- A pedigree-based map of crossovers and non-crossovers in aye-ayes (bioRxiv : the preprint server for biology · 2024Article
- Genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models.Nature communications · 2024Article
- Genetic characterization of a captive marmoset (Callithrix jacchus) colony using genotype-by-sequencing.American journal of primatology · 2024Article
- Adaptive functions of structural variants in human brain development.Science advances · 2024Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
29 authors.
Funding
Abstract
Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate in biomedical research, have the largest natural geographic distribution of any nonhuman primate, and have been the focus of much evolutionary and behavioral investigation. Consequently, rhesus macaques are one of the most thoroughly studied nonhuman primate species. However, little is known about genome-wide genetic variation in this species. A detailed understanding of extant genomic variation among rhesus macaques has implications for the use of this species as a model for studies of human health and disease, as well as for evolutionary population genomics. Whole-genome sequencing analysis of 133 rhesus macaques revealed more than 43.7 million single-nucleotide variants, including thousands predicted to alter protein sequences, transcript splicing, and transcription factor binding sites. Rhesus macaques exhibit 2.5-fold higher overall nucleotide diversity and slightly elevated putative functional variation compared with humans. This functional variation in macaques provides opportunities for analyses of coding and noncoding variation, and its cellular consequences. Despite modestly higher levels of nonsynonymous variation in the macaques, the estimated distribution of fitness effects and the ratio of nonsynonymous to synonymous variants suggest that purifying selection has had stronger effects in rhesus macaques than in humans. Demographic reconstructions indicate this species has experienced a consistently large but fluctuating population size. Overall, the results presented here provide new insights into the population genomics of nonhuman primates and expand genomic information directly relevant to primate models of human disease.
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