ArticleBiology open2017
Chicken muscle mitochondrial content appears co-ordinately regulated and is associated with performance phenotypes.
Article in Biology open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Tissue-Specific Mitochondrial Functionality and Mitochondrial-Related Gene Profiles in Response to Maternal Nutrition and One-Carbon Metabolite Supplementation During Early Pregnancy in Heifers.Animals : an open access journal from MDPI · 2025Article
- Calcium requirements for Japanese quail in the early growth period.Poultry science · 2025Article
- Association between mitochondrial DNA copy number and production traits in pigs.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- A high-resolution bovine mitochondrial co-expression network.Biology open · 2025Article
- Article
- Sperm-Borne Mitochondrial Activity Influenced by Season and Age of Holstein Bulls.International journal of molecular sciences · 2024Article
- Article
- Genetic and phenotypic associations of mitochondrial DNA copy number, SNP, and haplogroups with growth and carcass traits in beef cattle.Journal of animal science · 2023Article
- The hypoxia-inducible factor 1 pathway plays a critical role in the development of breast muscle myopathies in broiler chickens: a comprehensive review.Frontiers in physiology · 2023Review
- Influence of environmental factors and genetic variation on mitochondrial DNA copy number.Journal of animal science · 2022Article
- Reduced PGC-1β protein expression may underlie corticosterone inhibition of mitochondrial biogenesis and oxidative phosphorylation in chicken muscles.Frontiers in physiology · 2022Article
- Upstream Regulator Analysis of Wooden Breast Myopathy Proteomics in Commercial Broilers and Comparison to Feed Efficiency Proteomics in Pedigree Male Broilers.Foods (Basel, Switzerland) · 2021Article
- MitoFinder: Efficient automated large-scale extraction of mitogenomic data in target enrichment phylogenomics.Molecular ecology resources · 2020Article
- The distinct spatiotemporal distribution and effect of feed restriction on mtDNA copy number in broilers.Scientific reports · 2020Article
- Diet induced the change of mtDNA copy number and metabolism in Angus cattle.Journal of animal science and biotechnology · 2020Article
- Dysregulation of lipid metabolism and appearance of slow myofiber-specific isoforms accompany the development of Wooden Breast myopathy in modern broiler chickens.Scientific reports · 2019Article
- Marek's Disease Virus Infection Induced Mitochondria Changes in Chickens.International journal of molecular sciences · 2019Article
- Molecular Characterization of Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α (PGC1α) and Its Role in Mitochondrial Biogenesis in Blunt Snout Bream (Frontiers in physiology · 2018Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial content is a fundamental cellular bioenergetic phenotype. Previous work has hypothesised possible links between variation in muscle mitochondrial content and animal performance. However, no population screens have been performed in any production species. Here, we have designed a high throughput molecular approach to estimate mitochondrial content in commercial broilers. Technical validity was established using several approaches, including its performance in monoclonal DF-1 cells, cross-tissue comparisons in tissues with differing metabolic demands (white fat<breast muscle<drumstick muscle<heart muscle) and, as a negative control, a near absence of mtDNA amplification from whole blood. We screened breast muscle and thigh muscle in 80 birds individually phenotyped for 11 growth and development traits. Substantial individual variation (fivefold) was discovered in both breast and thigh muscle mitochondrial content. Interestingly, across birds we detected a very strong positive relationship between breast and thigh content (correlation coefficient 0.61; P<0.0001), consistent with coordinate regulatory control across the musculature. Further, breast muscle mitochondrial content is negatively correlated with breast muscle yield (-0.27; P=0.037), abdominal fat content (-0.31; P=0.017) and carcass yield (-0.26; P=0.045). Therefore, low breast muscle mitochondrial content is associated with more muscular birds possessing higher abdominal fat, the latter being in line with biomedical models of obesity. Finally, thigh mitochondrial content is negatively correlated with the bow out leg defect (-0.30; P=0.011). Overall, our data point to mitochondrial content as a promising consideration in predictive modelling of production traits.
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