ArticleThe Journal of nutrition2016
Sugar-Sweetened Beverage but Not Diet Soda Consumption Is Positively Associated with Progression of Insulin Resistance and Prediabetes.
Article in The Journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Non-Sugar-Sweetened Beverages and Risk of Chronic Diseases: An Umbrella Review of Meta-analyses of Prospective Cohort Studies.Nutrition reviews · 2025Pooled it
- Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies.European journal of epidemiology · 2020Pooled it
- The carbon isotope ratios of nonessential amino acids identify sugar-sweetened beverage (SSB) consumers in a 12-wk inpatient feeding study of 32 men with varying SSB and meat exposures.The American journal of clinical nutrition · 2021Trial
- Trial
- A high-sugar diet-induced animal model for insulin resistance, oxidative stress, and diabetic nephropathy: insights into empagliflozin's therapeutic potential.International urology and nephrology · 2026Article
- Burden of chronic kidney disease caused by dietary risks in China from 1990 to 2021: a systematic analysis and comparison with global levels.Journal of clinical biochemistry and nutrition · 2026Article
- Assessment of Machine Learning Model Performance for Clinical Prediction of Insulin Resistance in the Study of Cardiovascular Risk in Adolescents-ERICA.Journal of clinical medicine · 2026Article
- The carbon isotope ratio of alanine is a biomarker of added sugar and sugar-sweetened beverage intakes: a pooled analysis of 4 studies.The American journal of clinical nutrition · 2025Article
- Evaluating sugar-sweetened beverage tax effects: online price and sales data from grocers in Canada.Health promotion international · 2025Article
- Impact of carbohydrate quality on the association between low-carbohydrate diet scores and longitudinal changes of cardiometabolic risk factors.Nutrition journal · 2025Article
- Use of technology in prediabetes and precision prevention.Journal of diabetes investigation · 2025Review
- Association Between Coffee Consumption and Glucose Metabolism Markers in Korean Adults.Nutrients · 2025Article
- The mediating roles of anthropo-metabolic biomarkers on the association between beverage consumption and breast cancer risk.Nutrition journal · 2025Article
- A missing link: The interdependence between sugar-sweetened beverage and cigarette consumption from China.PloS one · 2025Article
- Diet Coke's chronic daily intake in female albino rats: Biochemical and histopathological effects on certain hematological and reproductive parameters.Open veterinary journal · 2025Article
- Redesigning Pharmacy to Improve Public Health Outcomes: Expanding Retail Spaces for Digital Therapeutics to Replace Consumer Products That Increase Mortality and Morbidity Risks.Pharmacy (Basel, Switzerland) · 2024Article
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- Soda intake influences phenotype, antioxidants and inflammatory status in high protein-fed wistar rats.Heliyon · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPrevious studies have shown an inconsistent relation between habitual beverage consumption and insulin resistance and prediabetes.
objectiveThe objective of the present study was to test the hypothesis that the consumption of sugar-sweetened beverages (SSBs), rather than diet soda, is associated with long-term progression of insulin resistance and the development of prediabetes.
methodsWe analyzed the prospective association between cumulative mean consumption of SSBs or diet soda and incident prediabetes (n = 1685) identified across a median of 14 y of follow-up in participants [mean ± SD age: 51.9 ± 9.2 y; 59.6% women; mean ± SD body mass index (BMI; kg/m
resultsAfter adjustment for multiple potential confounders, including baseline BMI, we observed that SSB intake was positively associated with incident prediabetes (P-trend < 0.001); the highest SSB consumers (>3 servings/wk; median: 6 servings/wk) had a 46% higher risk of developing prediabetes than did the SSB nonconsumers (HR: 1.46; 95% CI: 1.16, 1.83). Higher SSB intake was also associated with a greater increase in HOMA-IR (P-trend = 0.006). No prospective associations were observed between diet soda intake and risk of prediabetes (P-trend = 0.24) or changes in HOMA-IR (P-trend = 0.25). These associations were similar after additional adjustment for change in BMI.
conclusionRegular SSB intake, but not diet soda intake, is associated with a greater increase in insulin resistance and a higher risk of developing prediabetes in a group of middle-aged adults.
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