Evidence map›Paper›PMID 27934581›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2016

Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016.

Pieter L A Fraaij, Enno D Wildschut, Robert J Houmes, Corien M Swaan, Christian J Hoebe, H C C de Jonge, Paulien Tolsma, Isme de Kleer, Suzan D Pas, Bas B Oude Munnink and 10 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Influenza.Nature reviews. Disease primers · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Human infections with Eurasian avian-like swine influenza virus detected by coincidence via routine respiratory surveillance systems, the Netherlands, 2020 to 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Zoonotic infection with swine A/H1Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020
    Article
  17. Avian influenza overview November 2019- February2020.EFSA journal. European Food Safety Authority · 2020
    Article
  18. Article
  19. Article
  20. Novel influenza A viruses and pandemic threats.Lancet (London, England) · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 1 country.

Pieter L A FraaijDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
Enno D WildschutIntensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia, Rotterdam, The Netherlands.
Robert J HoumesIntensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia, Rotterdam, The Netherlands.
Corien M SwaanCentre for Infectious Disease Control-National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Christian J HoebeDepartment of Sexual Health, Infectious Diseases and Environmental Health, Public Health Service South Limburg, Geleen, The Netherlands.
H C C de JongeGemeentelijke Gezondheidsdienst Rotterdam-Rijnmond, Rotterdam, The Netherlands.
Paulien TolsmaGemeentelijke Gezondheidsdienst Brabant zuidoost, Eindhoven, The Netherlands.
Isme de KleerDepartment of Paediatrics, Subdivision of pulmonary medicine, Erasmus MC - Sophia, Rotterdam, The Netherlands.
Suzan D PasDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
Bas B Oude MunninkDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
My V T PhanDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
Theo M BestebroerDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
R Shanty RoosenhoffDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
Jeroen J A van KampenDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
Matthew CottenDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
Nancy BeerensWageningen Bioveterinary reseach- Wageningen University and Research, Lelystad, the Netherlands.
Ron A M FouchierDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
Johannes H van den KerkhofCentre for Infectious Disease Control-National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Aura TimenCentre for Infectious Disease Control-National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Marion P KoopmansDepartment of Viroscience Erasmus MC, Rotterdam, The Netherlands.
Erasmus MC · NLErasmus University Rotterdam · NLErasmus MC - Sophia Children’s Hospital · NLNational Institute for Public Health and the Environment · NLGGD Brabant-Zuidoost · NLGGD Rotterdam-Rijnmond · NLMaastricht University · NLWageningen University & Research · NL

Funding

Medical Research Council MC_UU_12014/12NIAID NIH HHS HHSN272201400008C
6 · The paper itself

Abstract

In October 2016, a severe infection with swine influenza A(H1N1) virus of the Eurasian avian lineage occurred in a child with a previous history of eczema in the Netherlands, following contact to pigs. The patient's condition deteriorated rapidly and required life support through extracorporeal membrane oxygenation. After start of oseltamivir treatment and removal of mucus plugs, the patient fully recovered. Monitoring of more than 80 close unprotected contacts revealed no secondary cases.

Indexed as

Extracorporeal Membrane OxygenationAnimalsAntiviral AgentsHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanIntensive Care Units, PediatricNetherlandsOrthomyxoviridae InfectionsOseltamivirReal-Time Polymerase Chain ReactionRespiratory Tract InfectionsSevere Acute Respiratory SyndromeSwineSwine DiseasesTreatment OutcomeAntiviral AgentsOseltamivirChildrenECMOInfluenzaSevereSwine

Identifiers

PMID27934581
PMCPMC5388114
OpenAlexW2560641093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.