Evidence map›Paper›PMID 27934359›Full record

ArticleOrganic letters2016

Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues.

Kayla J Temple, Elia N Wright, Carol A Fierke, Richard A Gibbs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kayla J TempleDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University , West Lafayette, Indiana 47907, United States.
Elia N WrightDepartments of Biological Chemistry and Chemistry, University of Michigan , Ann Arbor, Michigan 48109, United States.
Carol A FierkeDepartments of Biological Chemistry and Chemistry, University of Michigan , Ann Arbor, Michigan 48109, United States.
Richard A GibbsDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University , West Lafayette, Indiana 47907, United States.

Funding

STRUCTURE/FUNCTION OF ZINC METALLOPROTEINSR01GM040602 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FIERKE, CAROL A · 1993 to 2017
$6.0M
Development of Risk and Early Detection Biomarker for Small Cell Lung CancerU01CA213285 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HANASH, SAMIR M · 2017 to 2021
$2.6M
CHEMICAL PROBES OF PROTEIN PRENYLATIONR01CA078819 · NCI · WAYNE STATE UNIVERSITY · PI GIBBS, RICHARD A · 1998 to 2007
$1.1M
NCI NIH HHS R01 CA078819NCI NIH HHS U01 CA213285NIGMS NIH HHS R01 GM040602
6 · The paper itself

Abstract

A set of synthetic approaches was developed and applied to the synthesis of eight frame-shifted isoprenoid diphosphate analogues. These analogues were designed to increase or decrease the methylene units between the double bonds and/or the pyrophosphate moieties of the isoprenoid structure. Evaluation of mammalian GGTase-I and FTase revealed that small structural changes can result in substantial changes in substrate activity.

Indexed as

Alkyl and Aryl TransferasesDiphosphatesEnzyme InhibitorsFarnesyltranstransferaseMolecular StructureTerpenesAlkyl and Aryl TransferasesDiphosphatesEnzyme InhibitorsFarnesyltranstransferasegeranylgeranyltransferase type-ITerpenes

Identifiers

PMID27934359
PMCPMC6020017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.