ArticleAnalytical chemistry2016
Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations Using Compression Ratio Ion Mobility Programming.
Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Chiral Carbohydrate Adducts are Effective for Enantiomeric Ion Mobility Separations.Journal of the American Society for Mass Spectrometry · 2026Article
- Spatial Ion Compression without Loss of Resolution on a Cyclic Ion Mobility Spectrometry-Mass Spectrometry Platform.Analytical chemistry · 2026Article
- The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses.Advances in experimental medicine and biology · 2026Review
- Assessment of Variable Traveling Wave Profiles for Small-Molecule Applications in Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS).Journal of the American Society for Mass Spectrometry · 2025Article
- Ion confinement and separation using asymmetric electrodynamic fields in structures for lossless ion manipulations.Rapid communications in mass spectrometry : RCM · 2024Article
- Altering Conformational States of Dynamic Ion Populations using Traveling Wave Structures for Lossless Ion Manipulations.Analytical chemistry · 2024Article
- Evaluating dynamic traveling wave profiles for the enhancement of separation and sensitivity in traveling wave structures for lossless ion manipulations.Journal of chromatography. A · 2023Article
- SLIM Tricks: Tools, Concepts, and Strategies for the Development of Planar Ion Guides.Journal of the American Society for Mass Spectrometry · 2023Article
- Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers.Frontiers in molecular biosciences · 2023Review
- Evaluating the Utility of Temporal Compression in High-Resolution Traveling Wave-Based Cyclic Ion Mobility Separations.ACS measurement science au · 2022Article
- Effect of Traveling Waveform Profiles on Collision Cross Section Measurements in Structures for Lossless Ion Manipulations.Journal of the American Society for Mass Spectrometry · 2022Article
- Implementation of Ion Mobility Spectrometry-Based Separations in Structures for Lossless Ion Manipulations (SLIM).Methods in molecular biology (Clifton, N.J.) · 2022Article
- Resolving Power and Collision Cross Section Measurement Accuracy of a Prototype High-Resolution Ion Mobility Platform Incorporating Structures for Lossless Ion Manipulation.Journal of the American Society for Mass Spectrometry · 2021Article
- Evaluation of Waveform Profiles for Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations.Journal of the American Society for Mass Spectrometry · 2021Article
- Ion Mobility Spectrometry with High Ion Utilization Efficiency Using Traveling Wave-Based Structures for Lossless Ion Manipulations.Analytical chemistry · 2020Article
- Rapid and Simultaneous Characterization of Drug Conjugation in Heavy and Light Chains of a Monoclonal Antibody Revealed by High-Resolution Ion Mobility Separations in SLIM.Analytical chemistry · 2020Article
- Traveling-Wave-Based Electrodynamic Switch for Concurrent Dual-Polarity Ion Manipulations in Structures for Lossless Ion Manipulations.Analytical chemistry · 2019Article
- SLIM Ultrahigh Resolution Ion Mobility Spectrometry Separations of Isotopologues and Isotopomers Reveal Mobility Shifts due to Mass Distribution Changes.Analytical chemistry · 2019Article
- Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses.Analytical and bioanalytical chemistry · 2019Article
- Opening new paths for biological applications of ion mobility - mass spectrometry using Structures for Lossless Ion Manipulations.Trends in analytical chemistry : TRAC · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
In this work we report an approach for spatial and temporal gas-phase ion population manipulation, wherein we collapse ion distributions in ion mobility (IM) separations into tighter packets providing higher sensitivity measurements in conjunction with mass spectrometry (MS). We do this for ions moving from a conventional traveling wave (TW)-driven region to a region where the TW is intermittently halted or "stuttered". This approach causes the ion packets spanning a number of TW-created traveling traps (TT) to be redistributed into fewer TT, resulting in spatial compression. The degree of spatial compression is controllable and determined by the ratio of stationary time of the TW in the second region to its moving time. This compression ratio ion mobility programming (CRIMP) approach has been implemented using "structures for lossless ion manipulations" (SLIM) in conjunction with MS. CRIMP with the SLIM-MS platform is shown to provide increased peak intensities, reduced peak widths, and improved signal-to-noise (S/N) ratios with MS detection. CRIMP also provides a foundation for extremely long path length and multipass IM separations in SLIM providing greatly enhanced IM resolution by reducing the detrimental effects of diffusional peak broadening and increasing peak widths.
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Registered trials
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