ReviewScoliosis and spinal disorders2016
Genetics and pathogenesis of idiopathic scoliosis.
Review in Scoliosis and spinal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05059561 (Temperament and Character Traits in Young Men Diagnosed With Idiopathic Scoliosis), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Temperament and Character Traits in Young Men Diagnosed With Idiopathic Scoliosis
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Pooled it
- Risk of Scoliosis in Adolescent Female Rhythmic Gymnasts Compared with Healthy Peers: A Cross-Sectional Study Using the Scoliosis Tele-Screening Test.Sports health · 2026Article
- Deletion of aJOR spine · 2026Article
- Circulating microRNA signatures for diagnosis and prediction of curve progression in pediatric patients with idiopathic scoliosis.Journal of orthopaedic surgery and research · 2026Article
- Genome-wide association study identifiesPeerJ · 2026Article
- Clinical and genetic evidence from East Asian cohorts linking family history burden and menarche timing to curve severity in adolescent idiopathic scoliosis.Frontiers in endocrinology · 2026Article
- Patient education strategies in pediatric orthopaedics: using ChatGPT to answer frequently asked questions on scoliosis.Spine deformity · 2025Article
- Sensory integration and spinal structure in AIS: is there a functional-structural association?Journal of orthopaedic surgery and research · 2025Article
- Influence of Main Thoracic and Thoracic Kyphosis Morphology on Gait Characteristics in Adolescents with Idiopathic Scoliosis: Gait Analysis Using an Inertial Measurement Unit.Sensors (Basel, Switzerland) · 2025Article
- Difference in clinical presentation and surgical outcomes in pediatric and adult patients with Chiari malformation type 1: a single center retrospective study.Acta neurochirurgica · 2025Article
- Barriers and Facilitators in Proxy Decision-Making for Financial Support in Adolescent Idiopathic Scoliosis: A Qualitative Study of Family Caregivers Using the COM-B Model.Patient preference and adherence · 2025Article
- Comprehensive genetic screening of 70 severe adolescent idiopathic scoliosis probands reveals novel pathogenic variants and syndromic associations.Frontiers in medicine · 2025Article
- Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice.Human molecular genetics · 2024Article
- Investigating the Differential Circulating microRNA Expression in Adolescent Females with Severe Idiopathic Scoliosis: A Proof-of-Concept Observational Clinical Study.International journal of molecular sciences · 2024Observational
- Menarche in Scoliotic and Non-Scoliotic Balkan Girls and the Relationship between Menarche and the Laterality of Scoliotic Curves.Journal of clinical medicine · 2023Article
- Is Shoulder Imbalance a Useful Parameter in the Screening of Idiopathic Scoliosis? A Preliminary Study.Revista brasileira de ortopedia · 2023Article
- A New Clinical Tool for Scoliosis Risk Analysis: Scoliosis Tele-Screening Test.Asian spine journal · 2023Article
- Radiograph-comparable image synthesis for spine alignment analysis using deep learning with prospective clinical validation.EClinicalMedicine · 2023Article
- Whole-Exome Sequencing Identifies Genetic Variants for Severe Adolescent Idiopathic Scoliosis in a Taiwanese Population.Journal of personalized medicine · 2022Article
- Is There a Relationship between Idiopathic Scoliosis and Body Mass? A Scoping Review.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from very rare or even private to very common. The most promising candidate genes are highlighted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.