Evidence map›Paper›PMID 27933316›Full record

ArticleMolecular therapy oncolytics2016

Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice.

Eric Bartee, Mee Y Bartee, Bjarne Bogen, Xue-Zhong Yu

Abstract read
In one paragraph

Article in Molecular therapy oncolytics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. OncolyticTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Oncolytic herpes simplex virus infects myeloma cellsMolecular therapy oncolytics · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  13. Oncolytic Virotherapy with Myxoma Virus.Journal of clinical medicine · 2020
    Review
  14. Optimizing oncolytic virotherapy in cancer treatment.Nature reviews. Drug discovery · 2019
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eric BarteeDepartment of Microbiology and Immunology, Medical University of South Carolina , Charleston, South Carolina.
Mee Y BarteeDepartment of Microbiology and Immunology, Medical University of South Carolina , Charleston, South Carolina.
Bjarne BogenInstitute of Immunology, KG Jebsen Centre for Research on Influenza Vaccines and Centre for Immune Regulation, University of Oslo and Oslo University Hospital , Oslo, Norway.
Xue-Zhong YuDepartment of Microbiology and Immunology, Medical University of South Carolina , Charleston, South Carolina.

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jian Ouyang · 2009 to 2026
$42.7M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
Treatment of multiple myeloma using oncolytic myxoma virusR01CA194090 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BARTEE, ERIC CARTER · 2016 to 2020
$1.7M
Treatment of transplanted and established multiple myeloma using oncolytic myxomaK22AI095372 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BARTEE, ERIC CARTER · 2013 to 2014
$262k
NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR001450NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA194090NIAID NIH HHS K22 AI095372
6 · The paper itself

Abstract

Multiple myeloma is an incurable malignancy of plasma B-cells. Traditional chemotherapeutic regimes often induce initial tumor regression; however, virtually all patients eventually succumb to relapse caused by either reintroduction of disease during autologous transplant or expansion of chemotherapy resistant minimal residual disease. It has been previously demonstrated that an oncolytic virus known as myxoma can completely prevent myeloma relapse caused by reintroduction of malignant cells during autologous transplant. The ability of this virus to treat established residual disease

Identifiers

PMID27933316
PMCPMC5142464

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.