Evidence map›Paper›PMID 27933161›Full record

Trial reportImmunity, inflammation and disease2016

Parallel reductions of IgE and exhaled nitric oxide after optimized anti-inflammatory asthma treatment.

Jörgen Syk, Andrei Malinovschi, Magnus P Borres, Anna-Lena Undén, Anna Andreasson, Mats Lekander, Kjell Alving

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Immunity, inflammation and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jörgen SykDepartment of NeurobiologyCare Sciences and Society, Karolinska InstitutetStockholmSweden; Centre for Allergy Research, Karolinska InstitutetStockholmSweden.
Andrei MalinovschiDepartment of Medical Sciences Clinical Physiology, Uppsala University Uppsala Sweden.
Magnus P BorresDepartment of Women's and Children's Health Uppsala University Uppsala Sweden.
Anna-Lena UndénDepartment of Neurobiology Care Sciences and Society, Karolinska Institutet Stockholm Sweden.
Anna AndreassonDepartment of NeurobiologyCare Sciences and Society, Karolinska InstitutetStockholmSweden; Stress Research InstituteStockholm UniversityStockholmSweden.
Mats LekanderStress Research InstituteStockholm UniversityStockholmSweden; Department of Clinical NeuroscienceKarolinska InstitutetStockholmSweden.
Kjell AlvingDepartment of Women's and Children's Health Uppsala University Uppsala Sweden.
Karolinska Institutet · SEUppsala University · SEStockholm University · SEUppsala University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoglobulin E (IgE) is crucial for the development of airway inflammation in atopic asthma, and inhibition of IgE using monoclonal antibodies is now part of asthma therapy. However, the impact of ordinary anti-inflammatory treatment on IgE is unclear. The aim of this study was to investigate if optimization of treatment with inhaled corticosteroid (ICS) and leukotriene-receptor antagonist (LTRA) according to symptoms or exhaled nitric oxide (F

Indexed as

Anti-Asthmatic AgentsAsthmaBreath TestsExhalationFollow-Up StudiesHumansImmunoglobulin ENitric OxideQuality of LifeAnti-Asthmatic AgentsImmunoglobulin ENitric OxideAsthmaasthma controlatopybreath testcorticosteroidFENOimmunoglobulin Eleukotriene‐receptor antagonistquality of life

Identifiers

PMID27933161
PMCPMC4879464
OpenAlexW2298105018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.