Evidence map›Paper›PMID 27933160›Full record

ArticleImmunity, inflammation and disease2016

Post-sensitization administration of non-digestible oligosaccharides and

Betty C A M van Esch, Suzanne Abbring, Mara A P Diks, Gemma M Dingjan, Lucien F Harthoorn, A Paul Vos, Johan Garssen

Open access · goldAbstract read
In one paragraph

Article in Immunity, inflammation and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Synbiotic Combination ofJournal of microbiology and biotechnology · 2026
    Article
  4. The interplay between probiotics and mast cells in gut inflammation: a mini-review.Frontiers in cellular and infection microbiology · 2026
    Review
  5. Synergistic Synbiotic-ContainingFoods (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Betty C A M van EschFaculty of ScienceDivison of PharmacologyUtrecht Institute for Pharmaceutical SciencesUtrecht UniversityUtrechtThe Netherlands; Nutricia ResearchUtrechtThe Netherlands.
Suzanne AbbringFaculty of Science Divison of Pharmacology Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht The Netherlands.
Mara A P DiksFaculty of Science Divison of Pharmacology Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht The Netherlands.
Gemma M DingjanFaculty of Science Divison of Pharmacology Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht The Netherlands.
Lucien F HarthoornNutricia Research Nutricia Advanced Medical Nutrition Utrecht the Netherlands.
A Paul VosFaculty of ScienceDivison of PharmacologyUtrecht Institute for Pharmaceutical SciencesUtrecht UniversityUtrechtThe Netherlands; Nutricia ResearchNutricia Advanced Medical NutritionUtrechtthe Netherlands.
Johan GarssenFaculty of ScienceDivison of PharmacologyUtrecht Institute for Pharmaceutical SciencesUtrecht UniversityUtrechtThe Netherlands; Nutricia ResearchUtrechtThe Netherlands.
Utrecht University · NLNutricia Research (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To support dietary management of severe cow's milk allergic infants, a synbiotic mixture of non-digestible oligosaccharides and

Indexed as

Bifidobacterium breveAnimalsCattleChickensDisease Models, AnimalFemaleFood HypersensitivityHumansInfantMiceMice, Inbred BALB COligosaccharidesOvalbuminSynbioticsOligosaccharidesOvalbuminacute allergic skin responseBifidobacterium breve M‐16Vcow's milk allergyFOSfructo‐oligosaccharidegalectin‐9immunoglobulinsinulinmast cellnon‐digestible oligosaccharidesprebioticsprobioticspropionic acidregulatory T‐cellsshort chain fatty acidssynbioticsT cell subsetsTh1‐cells

Identifiers

PMID27933160
PMCPMC4879462
OpenAlexW2306671083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.