Evidence map›Paper›PMID 27933122›Full record

ReviewGastroenterology research2009

Molecular Markers in the Pathogenesis of Cholangiocarcinoma: Potential for Early Detection and Selection of Appropriate Treatment.

Cornelia Braicu, Claudia Burz, Ioana Berindan-Neagoe, Ovidiu Balacescu, Marcel Tantau, Victor Cristea, Alexandru Irimie

Open access · hybridAbstract readReview
In one paragraph

Review in Gastroenterology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. A review of the impact of obesity on common gastrointestinal malignancies.Integrative cancer science and therapeutics · 2017
    Article
  3. Article
  4. Obesity and cholangiocarcinoma.World journal of gastroenterology · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cornelia BraicuCancer Institut "I Chiricuta", Cluj-Napoca, Romania.
Claudia BurzUniversity of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
Ioana Berindan-NeagoeCancer Institut "I Chiricuta", Cluj-Napoca, Romania; University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
Ovidiu BalacescuCancer Institut "I Chiricuta", Cluj-Napoca, Romania.
Marcel TantauUniversity of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
Victor CristeaUniversity of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
Alexandru IrimieCancer Institut "I Chiricuta", Cluj-Napoca, Romania; University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
Institute of Oncology Prof. Dr. Ion Chiricuta · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholangiocarcinoma (CC) is a primary malignancy that arises from cholangiocytes, the epithelial cells lining the bile duct livers. The worldwide incidence of CC is increasing and despite of combined therapeutic strategies, its prognosis remains poor. Till now surgery remains the only curative treatment modality. Over the past years, several important studies have yielded new insights into the molecular mechanisms of cholangiocarcinoma. This review focused on critical molecular player during the development from inflammation and cellular and molecular pathogenesis of this disease. The novel prophylactic and therapeutic approach deals especially the molecules involved in inflammation of cholangiocite or those related to promotion and progression of CC. The elucidation of their specific effects and interaction of this complex mechanism will accelerate the development of new biomarker for early detection and predictor factors outcome in CC.

Indexed as

CancerCholangiocarcinomaMarkersTarget therapies

Identifiers

PMID27933122
PMCPMC5139703
OpenAlexW2120607660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.