Evidence map›Paper›PMID 27933100›Full record

ArticleBiotechnology for biofuels2016

Genome and methylome of the oleaginous diatom

Jesse C Traller, Shawn J Cokus, David A Lopez, Olga Gaidarenko, Sarah R Smith, John P McCrow, Sean D Gallaher, Sheila Podell, Michael Thompson, Orna Cook and 7 more

Open access · goldAbstract read
In one paragraph

Article in Biotechnology for biofuels, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 111 citations in OpenAlex.

  1. Allele-specific methylation ofScience advances · 2026
    Article
  2. Article
  3. The genome of Pleurosigma provides insights into the evolutionary adaptations of pelagic diatoms.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  4. Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Genetic engineering in diatoms: advances and prospects.The Plant journal : for cell and molecular biology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Jesse C TrallerScripps Institution of Oceanography, University California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0202 USA.
Shawn J CokusInstitute for Genomics and Proteomics, University of California, Los Angeles, CA 90095 USA.
David A LopezInstitute for Genomics and Proteomics, University of California, Los Angeles, CA 90095 USA.
Olga GaidarenkoScripps Institution of Oceanography, University California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0202 USA.
Sarah R SmithScripps Institution of Oceanography, University California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0202 USA ; J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037 USA.
John P McCrowJ. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037 USA.
Sean D GallaherInstitute for Genomics and Proteomics, University of California, Los Angeles, CA 90095 USA ; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095 USA.
Sheila PodellScripps Institution of Oceanography, University California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0202 USA.
Michael ThompsonInstitute for Genomics and Proteomics, University of California, Los Angeles, CA 90095 USA.
Orna CookScripps Institution of Oceanography, University California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0202 USA.
Marco MorselliInstitute for Genomics and Proteomics, University of California, Los Angeles, CA 90095 USA.
Artur JaroszewiczInstitute for Genomics and Proteomics, University of California, Los Angeles, CA 90095 USA.
Eric E AllenScripps Institution of Oceanography, University California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0202 USA.
Andrew E AllenScripps Institution of Oceanography, University California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0202 USA ; J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037 USA.
Sabeeha S MerchantDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095 USA.
Matteo PellegriniInstitute for Genomics and Proteomics, University of California, Los Angeles, CA 90095 USA.
Mark HildebrandScripps Institution of Oceanography, University California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0202 USA.
University of California, Los Angeles · USScripps Institution of Oceanography · USJ. Craig Venter Institute · US

Funding

Roles of sumoylation and alternative polyadenylation in cellular reprogrammingP01GM099134 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PLATH, KATHRIN · 2011 to 2021
$20.3M
Molecular Basis of Hyper lgE ImmunodeficiencyR01AI065617 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Talal Amine Chatila · 2006 to 2026
$10.9M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
NHGRI NIH HHS T32 HG002536NIAID NIH HHS R01 AI065617NIGMS NIH HHS P01 GM099134
6 · The paper itself

Abstract

backgroundImprovement in the performance of eukaryotic microalgae for biofuel and bioproduct production is largely dependent on characterization of metabolic mechanisms within the cell. The marine diatom

resultsWe sequenced the nuclear genome and methylome of this oleaginous diatom to identify the genetic traits that enable substantial accumulation of triacylglycerol. The genome is comprised of highly methylated repetitive sequence, which does not significantly change under silicon starved lipid induction, and data further suggests the primary role of DNA methylation is to suppress DNA transposition. Annotation of pivotal glycolytic, lipid metabolism, and carbohydrate degradation processes reveal an expanded enzyme repertoire in

conclusionsFunctional annotation and detailed cross-species comparison of key carbon rich processes in

Indexed as

Algae biofuelCarbon metabolismCyclotella crypticaDiatomDNA methylationGenome sequence

Identifiers

PMID27933100
PMCPMC5124317
OpenAlexW2556829150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.