Evidence map›Paper›PMID 27933063›Full record

ArticleFrontiers in immunology2016

Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.

Ernna H Oliveira, Claudia Macedo, Cristhianna V Collares, Ana Carolina Freitas, Paula Barbim Donate, Elza T Sakamoto-Hojo, Eduardo A Donadi, Geraldo A Passos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. The Thymus as a Mirror of the Body's Gene Expression.Advances in experimental medicine and biology · 2025
    Review
  2. Review
  3. The single-cell transcriptome of mTECs and CD4Frontiers in immunology · 2024
    Article
  4. Insm1 regulates mTEC development and immune tolerance.Cellular & molecular immunology · 2023
    Article
  5. Article
  6. Article
  7. Twenty Years of AIRE.Frontiers in immunology · 2018
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ernna H OliveiraMolecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
Claudia MacedoMolecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
Cristhianna V CollaresMolecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
Ana Carolina FreitasDepartment of Pathology, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
Paula Barbim DonateMolecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
Elza T Sakamoto-HojoDepartment of Biology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo (USP) , São Paulo , Brazil.
Eduardo A DonadiDepartment of Clinical Medicine, Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
Geraldo A PassosMolecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP), São Paulo, Brazil; Discipline of Genetics and Molecular Biology, Department of Morphology, Physiology and Basic Pathology, School of Dentistry of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream posttranscriptional controller in these cells and that variation in its expression might be associated with changes in the interactions between miRNAs and the mRNAs encoding PTAs. We demonstrated that downregulation of Aire

Indexed as

Airein vivo gene knockdownmedullary thymic epithelial cellsmiRNA–mRNA interactionmiRNAspromiscuous gene expression

Identifiers

PMID27933063
PMCPMC5120147
OpenAlexW2556003805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.