Evidence map›Paper›PMID 27932882›Full record

ArticleInternational journal of nanomedicine

Sustained-release liquisolid compact tablets containing artemether-lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance.

Petra Obioma Nnamani, Agatha Adaora Ugwu, Emmanuel Chinedu Ibezim, Franklin Chimaobi Kenechukwu, Paul Achile Akpa, John-Dike Nwabueze Ogbonna, Nicholas Chinedu Obitte, Amelia Ngozi Odo, Maike Windbergs, Claus-Michael Lehr and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Petra Obioma NnamaniDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University, Saarbrücken, Germany.
Agatha Adaora UgwuDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Emmanuel Chinedu IbezimDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Franklin Chimaobi KenechukwuDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Paul Achile AkpaDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
John-Dike Nwabueze OgbonnaDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Nicholas Chinedu ObitteDepartment of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences.
Amelia Ngozi OdoDepartment of Human Kinetics and Health Education, University of Nigeria, Nsukka, Nigeria.
Maike WindbergsDepartment of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University, Saarbrücken, Germany.
Claus-Michael LehrDepartment of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University, Saarbrücken, Germany; PharmBioTec GmbH; Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbrücken, Germany.
Anthony Amaechi AttamaDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
University of Nigeria · NGHelmholtz Institute for Pharmaceutical Research Saarland · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to develop low-dose liquisolid tablets of two antimalarial drugs artemether-lumefantrine (AL) from a nanostructured lipid carrier (NLC) of lumefantrine (LUM) and estimate the potential of AL as an oral delivery system in malariogenic Wistar mice. LUM-NLCs were prepared by hot homogenization using Precirol

Indexed as

Patient ComplianceAnimalsAntimalarialsArtemether, Lumefantrine Drug CombinationArtemisininsCalorimetry, Differential ScanningDelayed-Action PreparationsDrug CarriersDrug CombinationsDrug LiberationEthanolaminesFluorenesHumansHydrogen-Ion ConcentrationKineticsLipidsAntimalarialsArtemether, Lumefantrine Drug CombinationArtemisininsDelayed-Action PreparationsDrug CarriersDrug CombinationsEthanolaminesFluorenesLipidsTabletsantiplasmodial activityartemisinin-based combination therapyliquisolid compactsmalariananostructured lipid carriers

Identifiers

PMID27932882
PMCPMC5135285
OpenAlexW2559280139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.