Evidence map›Paper›PMID 27932583›Full record

ArticleRNA (New York, N.Y.)2017

Inhibition of HIV-1 Gag-membrane interactions by specific RNAs.

Gabrielle C Todd, Alice Duchon, Jingga Inlora, Erik D Olson, Karin Musier-Forsyth, Akira Ono

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  3. The "basics" of HIV-1 assembly.PLoS pathogens · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gabrielle C ToddDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Alice DuchonDepartment of Chemistry and Biochemistry, Center for RNA Biology, and Center for Retrovirus Research, The Ohio State University, Columbus, Ohio 43210, USA.
Jingga InloraDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Erik D OlsonDepartment of Chemistry and Biochemistry, Center for RNA Biology, and Center for Retrovirus Research, The Ohio State University, Columbus, Ohio 43210, USA.
Karin Musier-ForsythDepartment of Chemistry and Biochemistry, Center for RNA Biology, and Center for Retrovirus Research, The Ohio State University, Columbus, Ohio 43210, USA.
Akira OnoDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA akiraono@umich.edu.ORCID 0000-0001-7841-851X
The Ohio State University · USUniversity of Michigan · US

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
RNA Binding and Packaging By Retroviral Gag ProteinsR01GM065056 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUSIER-FORSYTH, KARIN M · 2002 to 2018
$4.9M
CHEMISTRY/BIOLOGY TRAINING GRANTT32GM008512 · NIGMS · OHIO STATE UNIVERSITY · PI PEI, DEHUA · 1996 to 2016
$3.9M
Mechanisms that determine subcellular sites of HIV-1 assemblyR01AI071727 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ONO, AKIRA · 2007 to 2016
$3.6M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
PHYSICIAN-IMMUNOLOGIST TRAINING PROGRAMT32AI007527 · NIAID · WAYNE STATE UNIVERSITY · PI LISAK, ROBERT P · 1997 to 2001
$160k
Mechanism of HIV-1 gRNA-Gag interaction leading to selective genome packagingF31AI120868 · NIAID · OHIO STATE UNIVERSITY · PI OLSON, ERIK DAVID · 2016 to 2017
$64k
NIAID NIH HHS F31 AI120868NIAID NIH HHS R01 AI071727NIAID NIH HHS T32 AI007527NIAID NIH HHS T32 AI007528NIGMS NIH HHS R01 GM065056NIGMS NIH HHS T32 GM008512NIGMS NIH HHS T32 GM145304
6 · The paper itself

Abstract

HIV-1 particle assembly, which occurs at the plasma membrane (PM) of cells, is driven by the viral polyprotein Gag. Gag recognizes phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P

Indexed as

Aptamers, NucleotideBase PairingBase SequenceBinding SitesCell MembraneCloning, MolecularEscherichia coligag Gene Products, Human Immunodeficiency VirusGene ExpressionHIV-1HumansLiposomesNucleic Acid ConformationPhosphatidylinositol 4,5-DiphosphateProtein BindingRecombinant ProteinsAptamers, Nucleotidegag Gene Products, Human Immunodeficiency VirusLiposomesPhosphatidylinositol 4,5-DiphosphateRecombinant ProteinsRNA, TransferGagHIV-1membrane bindingretrovirus assemblytRNAviral RNA

Identifiers

PMID27932583
PMCPMC5311501
OpenAlexW2560258370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.