Evidence map›Paper›PMID 27932542›Full record

ArticleGenetics2017

H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying.

Ananya R Guntur, Bin Gou, Pengyu Gu, Ruo He, Ulrich Stern, Yang Xiang, Chung-Hui Yang

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. TRPA1 for Butterfly Eyespot Formation.International journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. A functional division ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Recent advances in the genetic basis of taste detection in Drosophila.Cellular and molecular life sciences : CMLS · 2020
    Review
  13. Color vision in insects: insights from Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ananya R GunturDepartment of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
Bin GouDepartment of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
Pengyu GuDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Ruo HeDepartment of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
Ulrich SternDepartment of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
Yang XiangDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Chung-Hui YangDepartment of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710 yang@neuro.duke.edu.
Duke University Hospital · USDuke University · USUniversity of Massachusetts Chan Medical School · US

Funding

Molecular Mechanisms of nociceptor sensitizationR01NS089787 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI XIANG, YANG · 2015 to 2019
$1.8M
Genetic Dissection of an Avoidance Circuit in DrosophilaR01GM100027 · NIGMS · DUKE UNIVERSITY · PI YANG, CHUNG-HUI · 2012 to 2016
$1.5M
NIGMS NIH HHS R01 GM100027NINDS NIH HHS R01 NS089787
6 · The paper itself

Abstract

The evolutionarily conserved TRPA1 channel can sense various stimuli including temperatures and chemical irritants. Recent results have suggested that specific isoforms of Drosophila TRPA1 (dTRPA1) are UV-sensitive and that their UV sensitivity is due to H

Indexed as

Ultraviolet RaysAnimalsChemoreceptor CellsDrosophila melanogasterDrosophila ProteinsFemaleHydrogen PeroxideIon ChannelsLocomotionOvipositionProtein IsoformsTasteTRPA1 Cation ChannelTRPC Cation ChannelsDrosophila ProteinsHydrogen PeroxideIon ChannelsProtein IsoformsTRPA1 Cation ChannelTrpA1 protein, DrosophilaTRPC Cation Channelsbitter-sensing neuronsDrosophila egg-layingdTRPA1UV-sensing

Identifiers

PMID27932542
PMCPMC5289849
OpenAlexW2560398307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.