Evidence map›Paper›PMID 27932478›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Most ApoL1 Is Secreted by the Liver.

Khuloud Shukha, Jessica L Mueller, Raymond T Chung, Michael P Curry, David J Friedman, Martin R Pollak, Anders H Berg

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 60 citations in OpenAlex.

  1. Differential regulation of basal and interferon-inducedAmerican journal of physiology. Renal physiology · 2026
    Article
  2. Germline-targeted baboon apolipoprotein L-1 protects mice against African trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. De novo rates of aProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Collapsing Glomerulopathy.Advances in kidney disease and health · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. The key role of NLRP3 and STING in APOL1-associated podocytopathy.The Journal of clinical investigation · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Khuloud ShukhaDivision of Nephrology, Department of Medicine and.
Jessica L MuellerHarvard Medical School, Boston, Massachusetts.
Raymond T ChungHarvard Medical School, Boston, Massachusetts.
Michael P CurryHarvard Medical School, Boston, Massachusetts.
David J FriedmanDivision of Nephrology, Department of Medicine and.
Martin R PollakDivision of Nephrology, Department of Medicine and mpollak@bidmc.harvard.edu.
Anders H BergHarvard Medical School, Boston, Massachusetts.
Harvard University · USBeth Israel Deaconess Medical Center · USHadassah Medical Center · IL

Funding

APOL1 variants: Understanding the basis of disparities in rates of kidney diseaseR01MD007092 · NIMHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FRIEDMAN, DAVID J, POLLAK, MARTIN R. · 2012 to 2021
$4.3M
Molecular Mechanism of APOL1 Associated Kidney DiseaseR01MD007898 · NIMHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ALPER, SETH LEO, POLLAK, MARTIN R. · 2013 to 2017
$2.2M
Patient-Oriented Research on Hepatitis in Special PopulationsK24DK078772 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, RAYMOND T · 2007 to 2016
$1.6M
The role of carbamylation in uremia associated heart diseaseK08HL121801 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BERG, ANDERS HAYDEN · 2014 to 2017
$588k
NHLBI NIH HHS K08 HL121801NIDDK NIH HHS K24 DK078772NIMHD NIH HHS R01 MD007092NIMHD NIH HHS R01 MD007898
6 · The paper itself

Abstract

Two coding sequence variants in the

Indexed as

Liver TransplantationApolipoprotein L1ApolipoproteinsGenotypeHumansLipoproteins, HDLLiverAPOL1 protein, humanApolipoprotein L1ApolipoproteinsLipoproteins, HDLapoptosisfocal segmental glomerulosclerosiskidney diseasePathophysiology of Renal Disease and Progressiontransplantation

Identifiers

PMID27932478
PMCPMC5373451
OpenAlexW2560745863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.