Evidence map›Paper›PMID 27932448›Full record

ArticleThe EMBO journal2017

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy.

Tomonori Kimura, Jingyue Jia, Suresh Kumar, Seong Won Choi, Yuexi Gu, Michal Mudd, Nicolas Dupont, Shanya Jiang, Ryan Peters, Farzin Farzam and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

227 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
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  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Role of autophagy in antiviral innate immunity.Cellular & molecular biology letters · 2026
    Review
  13. Endothelial Cell Secretome Alterations Induced by Inflammatory Stress.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Extracellular vesicles inEXO : beyond the cell · 2026
    Article
  20. Review

167 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tomonori KimuraDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Jingyue JiaDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Suresh KumarDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Seong Won ChoiDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Yuexi GuDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Michal MuddDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Nicolas DupontDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Shanya JiangDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Ryan PetersDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Farzin FarzamDepartment of Physics and Astronomy, University of New Mexico, Albuquerque, NM, USA.
Ashish JainMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0001-6549-2788
Keith A LidkeDepartment of Physics and Astronomy, University of New Mexico, Albuquerque, NM, USA.
Christopher M AdamsStanford University Mass Spectrometry, Stanford University, Stanford, CA, USA.
Terje JohansenMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0003-1451-9578
Vojo DereticDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA vderetic@salud.unm.edu.

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
UNM TRAININGP50GM085273 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI EDWARDS, JEREMY S · 2009 to 2018
$26.1M
Autophagy Against Tuberculosis and HIVR01AI111935 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DERETIC, VOJO P · 2014 to 2023
$7.0M
Pattern Recognition Receptors and Autophagy in Mtb Control in AIDSR01AI042999 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DERETIC, VOJO P · 1998 to 2017
$6.6M
Pattern Recognition Receptors and Autophagy in Mtb Control in AIDSR37AI042999 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI VOJO P DERETIC · 2018 to 2026
$4.7M
Autophagy-based HDT for tuberculosisUH2AI122313 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DERETIC, VOJO P, ELLNER, JERROLD J. · 2015 to 2016
$1.1M
NCI NIH HHS P30 CA118100NIAID NIH HHS R01 AI042999NIAID NIH HHS R01 AI111935NIAID NIH HHS R37 AI042999NIAID NIH HHS UH2 AI122313NIGMS NIH HHS P50 GM085273
6 · The paper itself

Abstract

Autophagy is a process delivering cytoplasmic components to lysosomes for degradation. Autophagy may, however, play a role in unconventional secretion of leaderless cytosolic proteins. How secretory autophagy diverges from degradative autophagy remains unclear. Here we show that in response to lysosomal damage, the prototypical cytosolic secretory autophagy cargo IL-1β is recognized by specialized secretory autophagy cargo receptor TRIM16 and that this receptor interacts with the R-SNARE Sec22b to recruit cargo to the LC3-II

Indexed as

AutophagyCell LineDNA-Binding ProteinsFerritinsHumansInterleukin-1betaMicrotubule-Associated ProteinsMonocytesQa-SNARE ProteinsQb-SNARE ProteinsQc-SNARE ProteinsR-SNARE ProteinsTranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesDNA-Binding ProteinsFerritinsInterleukin-1betaMAP1LC3A protein, humanMicrotubule-Associated ProteinsQa-SNARE ProteinsQb-SNARE ProteinsQc-SNARE ProteinsR-SNARE ProteinsSec22B protein, humanSNAP23 protein, humanSNAP29 protein, humanTranscription FactorsTRIM16 protein, humanTripartite Motif ProteinsUbiquitin-Protein Ligasesautophagygalectinsinflammasomelysosometuberculosis

Identifiers

PMID27932448
PMCPMC5210154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.