SynthesisBlood2017
Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function.
Open access · bronzeAbstract readLetterMeta-Analysis
In one paragraph
Synthesis in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review.Annals of internal medicine · 2018Pooled it
- Association of Sickle Cell Trait With Ischemic Stroke Among African Americans: A Meta-analysis.JAMA neurology · 2018Pooled it
- Racial disparities in cardiovascular manifestations among patients with sickle cell trait: analysis of national inpatient sample data (2016-2020).Annals of hematology · 2025Article
- The Not-So-Benign Sickle Cell Trait: A Case of Renal Medullary Carcinoma.Journal of community hospital internal medicine perspectives · 2024Article
- Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell Trait.International journal of molecular sciences · 2023Article
- Cardiovascular consequences of sickle cell disease.Biophysics reviews · 2022Review
- Health services use by children identified as heterozygous hemoglobinopathy mutation carriers via newborn screening.BMC pediatrics · 2021Article
- Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study.Journal of the American Heart Association · 2019Article
- The current state of sickle cell trait: implications for reproductive and genetic counseling.Hematology. American Society of Hematology. Education Program · 2018Review
- The current state of sickle cell trait: implications for reproductive and genetic counseling.Blood · 2018Review
Corrections and comments
- Commented on by
Authors and funding
25 authors at 16 institutions in 2 countries.
Natalie A BelloDivision of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY.ORCID 0000-0003-3257-3623
Hyacinth I HyacinthDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-1991-7463
Nicholas S RoetkerDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN.
Samantha R SealsCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS.
Rakhi P NaikDivision of Hematology, Johns Hopkins School of Medicine, Baltimore, MD.
Vimal K DerebailDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-7662-7497
Abhijit V KshirsagarDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Nigel S KeyDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
James G WilsonDepartment of Physiology and Biophysics, and.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.ORCID 0000-0002-9501-600X
Robert J AdamsDepartment of Neurology, Medical University of South Carolina, Charleston, SC.
Leonard D EgedeDepartment of Medicine, and.
W T LongstrethDepartment of Neurology and Department of Epidemiology, University of Washington, Seattle, WA.
Gaurav ChoudharyProvidence VA Medical Center, Brown University, Providence, RI.ORCID 0000-0001-9343-5481
Beatrice E GeeDepartment of Pediatrics, Morehouse School of Medicine, Atlanta, GA.
Austin L HughesDepartment of Biology, University of South Carolina, Columbia, SC.
Amil M ShahDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Matthew AllisonDivision of Preventive Medicine, University of California San Diego, San Diego, CA.
Gregory L BurkeDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
Aaron R FolsomDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN.
Cara L CartyFred Hutchinson Cancer Research Center, Seattle, WA; and.
Alexander P ReinerFred Hutchinson Cancer Research Center, Seattle, WA; and.
Scott D SolomonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Suma H KonetyDivision of Cardiology, University of Minnesota Medical Center, Minneapolis, MN.
Brigham and Women's Hospital · USUniversity of North Carolina at Chapel Hill · USFred Hutch Cancer Center · USUniversity of Minnesota · USUniversity of Mississippi Medical Center · USBrown University · USEmory University · USInstitute of Molecular Biology and Biophysics · RUJohns Hopkins University · USMedical University of South Carolina · USMorehouse School of Medicine · USUniversity of California San Diego · USUniversity of Minnesota Medical Center · USUniversity of South Carolina · USUniversity of Washington · USWake Forest University · US
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MSUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTERN01HC95159 · NHLBI · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2007 to 2014
$19.6MCellular and Molecular Mechanisms of Acute Lung Injury in Sickle Cell DiseaseU01HL117721 · NHLBI · EMORY UNIVERSITY · PI DEBAUN, MICHAEL R., JOINER, CLINTON H · 2013 to 2017
$9.4MTraining Program in Cardiovascular ResearchT32HL007374 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MITTLEMAN, MURRAY A · 1985 to 2019
$7.9MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95160 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL · 2007 to 2015
$7.7MTargeted Anticoagulant Therapy for Sickle Cell DiseaseU01HL117659 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KEY, NIGEL S., MACKMAN, NIGEL · 2013 to 2017
$7.6MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC95164 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, KIANG · 2007 to 2015
$7.0MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95161 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEA, STEVEN · 2007 to 2014
$6.4MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95165 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BURKE, GREGORY L · 2007 to 2014
$6.3MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95163 · NHLBI · UNIVERSITY OF MINNESOTA · PI FOLSOM, AARON R · 2007 to 2014
$6.1MTITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)N01HC95162 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY · 2007 to 2015
$6.0MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS K08 HL125100NHLBI NIH HHS K12 HL087097NHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS T32 HL007374NHLBI NIH HHS U01 HL117659NHLBI NIH HHS U01 HL117721NIA NIH HHS HHSN271201100004CNIDDK NIH HHS R56 DK104806NIH HHS HHSN263201500003IWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
PubMed holds no abstract for this paper.
Indexed as
Black or African AmericanFemaleHeart DiseasesHeart FailureHeterozygoteHumansMaleRisk FactorsSickle Cell Trait
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.