Evidence map›Paper›PMID 27932289›Full record

ReviewArchives of biochemistry and biophysics2017

Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling.

Aron B Fisher

Abstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Loss of Peroxiredoxin 6 Drives Age-Related Klf9/NF-Antioxidants (Basel, Switzerland) · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Decoding ferroptosis for cancer therapy.Nature reviews. Cancer · 2025
    Review
  10. Review
  11. Can the Quality of Semen Affect the Fertilisation Indices of Turkey Eggs?International journal of molecular sciences · 2025
    Article
  12. Review
  13. Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Aron B FisherInstitute for Environmental Medicine of the Department of Physiology, University of Pennsylvania, 3620 Hamilton Walk, 1 John Morgan Building, Philadelphia, PA, United States. Electronic address: abf@upenn.edu.

Funding

Role of Peroxiredoxin 6 in the Repair of Peroxidized Cell MembranesR01HL102016 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FISHER, ARON B. · 2010 to 2018
$4.6M
NHLBI NIH HHS R01 HL102016
6 · The paper itself

Abstract

Peroxiredoxin 6 represents a widely distributed group of peroxiredoxins that contain a single conserved cysteine in the protein monomer (1-cys Prdx). The cys when oxidized to the sulfenic form is reduced with glutathione (GSH) catalyzed by the π isoform of GSH-S-transferase. Three enzymatic activities of the protein have been described:1) peroxidase with H

Indexed as

1-Acylglycerophosphocholine O-AcyltransferaseAnimalsCatalysisCell MembraneDimerizationGlutathioneGlutathione TransferaseHumansHydrogen PeroxideHydrolysisMiceMice, TransgenicNADPOxidative StressPeroxiredoxin VIPhospholipases A21-Acylglycerophosphocholine O-AcyltransferaseGlutathioneGlutathione TransferaseHydrogen PeroxideNADPPeroxiredoxin VIPhospholipases A2Recombinant ProteinsAnti-oxidant defenseLysophospholipid acyl transferaseNADPH oxidasePhospholipase A(2)Phospholipid hydroperoxide glutathione peroxidasePhospholipid remodeling

Identifiers

PMID27932289
PMCPMC5810417

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.