Evidence map›Paper›PMID 27932287›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis.

Cynthia Azeredo Cordeiro, Erica Leandro Marciano Vieira, Natália Pessoa Rocha, Vinicius Monteiro Castro, Juliana Lambert Oréfice, Tatiana Barichello, Rogerio Alves Costa, Fernando Oréfice, Lucy Young, Antonio Lucio Teixeira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Neurotrophic Factors in Experimental Cerebral Acanthamoebiasis.International journal of molecular sciences · 2022
    Article
  2. Immunopathogenicity ofInternational journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Cynthia Azeredo CordeiroUniversidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil; Centro Brasileiro de Ciências Visuais, Belo Horizonte, MG, Brazil; Massachusetts Eye and Ear Infirmary, Retina Department, Boston, United States.
Erica Leandro Marciano VieiraUniversidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil.
Natália Pessoa RochaUniversidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil.
Vinicius Monteiro CastroUniversidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil; Centro Brasileiro de Ciências Visuais, Belo Horizonte, MG, Brazil.
Juliana Lambert OréficeCentro Brasileiro de Ciências Visuais, Belo Horizonte, MG, Brazil.
Tatiana BarichelloUniversidade do Extremo Sul Catarinense, Criciuma, SC, Brazil; The University of Texas Health Science Center at Houston, McGovern Medical School, Department of Psychiatry and Behavioral Sciences, Houston, United States.
Rogerio Alves CostaCentro Brasileiro de Ciências Visuais, Belo Horizonte, MG, Brazil.
Fernando OréficeCentro Brasileiro de Ciências Visuais, Belo Horizonte, MG, Brazil.
Lucy YoungMassachusetts Eye and Ear Infirmary, Retina Department, Boston, United States.
Antonio Lucio TeixeiraUniversidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil; The University of Texas Health Science Center at Houston, McGovern Medical School, Department of Psychiatry and Behavioral Sciences, Houston, United States. Electronic address: antonio.l.teixeira@uth.tmc.edu.
Universidade Federal de Minas Gerais · BRThe University of Texas Health Science Center at Houston · USFaculdade de Ciências Médicas de Minas Gerais · BRMassachusetts Eye and Ear Infirmary · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.

methodsTwenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.

resultsBDNF levels were significantly higher in patients before treatment when compared with controls (p=0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors.

conclusionBDNF may be released in the context of the active TR inflammatory response.

Indexed as

AdultBiomarkersBrain-Derived Neurotrophic FactorCase-Control StudiesChorioretinitisEnzyme-Linked Immunosorbent AssayFemaleGlial Cell Line-Derived Neurotrophic FactorHumansMaleNerve Growth FactorNerve Growth FactorsNeurotrophin 3Toxoplasmosis, OcularBiomarkersBrain-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic FactorNerve Growth FactorNerve Growth FactorsNeurotrophin 3neurotrophin 4Brain-derived neurotrophic factorRetinochoroiditisToxoplasma gondii

Identifiers

PMID27932287
PMCPMC9427644
OpenAlexW2560750339

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.