ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2017
Genetic diversity of coronaviruses in bats in Lao PDR and Cambodia.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04716543 (One-health Approach in Epidemiological Investigation of SARS-CoV-2 in Laos), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
One-health Approach in Epidemiological Investigation of SARS-CoV-2 in Laos
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Understanding zoonotic pathogens and risk factors from wildlife in Southeast Asia: a systematic literature review.The veterinary quarterly · 2025Pooled it
- Characterizing the Bat Virome of Vietnam: A Systematic Review of Viral Diversity and Zoonotic Potential.Viruses · 2025Pooled it
- Emerging zoonotic diseases in Southeast Asia in the period 2011-2022: a systematic literature review.The veterinary quarterly · 2024Pooled it
- Zoonotic neglected tropical diseases at the animal-human interface in the Greater Mekong Subregion: Two decades of surveillance in Laos and Cambodia.PLoS neglected tropical diseases · 2026Review
- Genetic diversity of alpha and betacoronaviruses in cave and temple-roosting bats in Vientiane Province, Lao PDR.PloS one · 2026Article
- A Roadmap of Primary Pandemic Prevention Through Spillover Investigation.Emerging infectious diseases · 2025Review
- Genetic characterization and pathogenicity analysis of three porcine epidemic diarrhea virus strains isolated from North China.Veterinary research · 2025Article
- Insights into cross-species infection: Porcine epidemic diarrhea virus infections in the rodent.Virologica Sinica · 2025Article
- Comparative Analysis of Quan and Watanabe Pan-Coronavirus Assays for Bat Coronavirus Diversity in Sarawak, East Malaysia.Journal of medical virology · 2025Article
- Study of coronavirus diversity in wildlife in Northern Cambodia suggests continuous circulation of SARS-CoV-2-related viruses in bats.Scientific reports · 2025Article
- Humoral Immunity Profiling to Pandemic and Bat-Derived Coronavirus Variants: A Geographical Comparison.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Differential prevalence and risk factors for infection with coronaviruses in bats collected from Yunnan Province, China.One health (Amsterdam, Netherlands) · 2024Article
- Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans.NPJ vaccines · 2024Article
- Article
- Generation of self-replicating airway organoids from the cave nectar batEmerging microbes & infections · 2023Article
- The coronavirus recombination pathway.Cell host & microbe · 2023Review
- One Health Surveillance Highlights Circulation of Viruses with Zoonotic Potential in Bats, Pigs, and Humans in Viet Nam.Viruses · 2023Article
- Targeted genomic sequencing with probe capture for discovery and surveillance of coronaviruses in bats.eLife · 2022Article
- Co-circulation of alpha- and beta-coronaviruses in Pteropus vampyrus flying foxes from Indonesia.Transboundary and emerging diseases · 2022Article
- SARS-CoV-2 host prediction based on virus-host genetic features.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 9 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
South-East Asia is a hot spot for emerging zoonotic diseases, and bats have been recognized as hosts for a large number of zoonotic viruses such as Severe Acute Respiratory Syndrome (SARS), responsible for acute respiratory syndrome outbreaks. Thus, it is important to expand our knowledge of the presence of viruses in bats which could represent a risk to humans. Coronaviruses (CoVs) have been reported in bat species from Thailand, China, Indonesia, Taiwan and the Philippines. However no such work was conducted in Cambodia or Lao PDR. Between 2010 and 2013, 1965 bats were therefore sampled at interfaces with human populations in these two countries. They were tested for the presence of coronavirus by consensus reverse transcription-PCR assay. A total of 93 samples (4.7%) from 17 genera of bats tested positive. Sequence analysis revealed the presence of potentially 37 and 56 coronavirus belonging to alpha-coronavirus (αCoV) and beta-CoV (βCoV), respectively. The βCoVs group is known to include some coronaviruses highly pathogenic to human, such as SARS-CoV and MERS-CoV. All coronavirus sequences generated from frugivorous bats (family Pteropodidae) (n=55) clustered with other bat βCoVs of lineage D, whereas one coronavirus from Pipistrellus coromandra fell in the lineage C of βCoVs which also includes the MERS-CoV. αCoVs were all detected in various genera of insectivorous bats and clustered with diverse bat αCoV sequences previously published. A closely related strain of PEDV, responsible for severe diarrhea in pigs (PEDV-CoV), was detected in 2 Myotis bats. We highlighted the presence and the high diversity of coronaviruses circulating in bats from Cambodia and Lao PDR. Three new bat genera and species were newly identified as host of coronaviruses, namely Macroglossus sp., Megaerops niphanae and Myotis horsfieldii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.