ArticleHuman genetics1989
Somatic pairing of chromosome 1 centromeres in interphase nuclei of human cerebellum.
Article in Human genetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 110 citations in OpenAlex.
- Modeling homologous chromosome recognition via nonspecific interactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A spatial genome aligner for resolving chromatin architectures from multiplexed DNA FISH.Nature biotechnology · 2023Article
- Review
- Long non-coding RNA SeT and miR-155 regulate the Tnfα gene allelic expression profile.PloS one · 2017Article
- Interallelic interaction and gene regulation in budding yeast.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Pairing and anti-pairing: a balancing act in the diploid genome.Current opinion in genetics & development · 2016Review
- Maternal Germinal Trisomy 21 in Down Syndrome.Journal of clinical medicine · 2014Article
- Homologue pairing in flies and mammals: gene regulation when two are involved.Genetics research international · 2012Article
- Controlled somatic and germline copy number variation in the mouse model.Current genomics · 2010Article
- On the paternal origin of trisomy 21 Down syndrome.Molecular cytogenetics · 2010Article
- Somatic pairing of chromosome 19 in renal oncocytoma is associated with deregulated EGLN2-mediated [corrected] oxygen-sensing response.PLoS genetics · 2008Article
- Article
- Drosophila under the lens: imaging from chromosomes to whole embryos.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- Visualization of interphase chromosomes in postmitotic cells of the human brain by multicolour banding (MCB).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
- Common themes and cell type specific variations of higher order chromatin arrangements in the mouse.BMC cell biology · 2005Article
- Spatial association of homologous pericentric regions in human lymphocyte nuclei during repair.Biophysical journal · 2005Article
- Fluorescence in situ hybridization (FISH) in diagnostic and investigative neuropathology.Brain pathology (Zurich, Switzerland) · 2002Review
- Higher levels of organization in the interphase nucleus of cycling and differentiated cells.Microbiology and molecular biology reviews : MMBR · 2000Review
- Somatic pairing of homologs in budding yeast: existence and modulation.Genes & development · 1999Article
- Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interphase nuclei isolated from paraffin-embedded tissue of four normal brains were hybridized with biotinated repetitive DNA probes specific for the (peri)centromeric regions of chromosomes 1 and 7. Hybridization results were visualized with a peroxidase-DAB system after which the number of specific signals per nucleus was counted using bright field microscopy. Using the probe specific for chromosome 7 (p7t1), both the cerebral and the cerebellar samples showed 2 spots in 82% and 83%, respectively, of the nuclei. In situ hybridization with the chromosome 1 probe (pUC1.77) showed two spots in 69% of the cerebral nuclei. In cerebellar samples, hybridization with pUC1.77 resulted in only one large spot per nucleus in 82% of the cells. The average spot size in nuclei with one signal was about 1.6 times as large as that in nuclei with two signals. These observations suggest that the single large spot in the cerebellar cells is not the result of monosomy of chromosome 1 but that it reflects somatic pairing of the two chromosome 1 centromeres. Based on the size and the fraction of nuclei with one large spot, the small granular neuron is the most likely candidate. The difference between cerebral and cerebellar samples indicates that this somatic pairing of chromosome 1 is a cell-type-dependent phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.