Evidence map›Paper›PMID 27931246›Full record

ArticleMolecular brain2016

Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT

Alastair S Garfield, Jennifer R Davies, Luke K Burke, Hannah V Furby, Lawrence S Wilkinson, Lora K Heisler, Anthony R Isles

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
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  6. Review
  7. Probiotic Influences on Motor Skills: A Review.Current neuropharmacology · 2023
    Review
  8. Article
  9. Review
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  11. Review
  12. Article
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  15. Article
  16. Article
  17. The 15q11.2 BP1-BP2 Microdeletion (International journal of molecular sciences · 2020
    Review
  18. Functional diversity of small nucleolar RNAs.Nucleic acids research · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Alastair S GarfieldCentre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
Jennifer R DaviesBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Pscyhology, Cardiff University, Cardiff, UK.
Luke K BurkeDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Hannah V FurbyBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Pscyhology, Cardiff University, Cardiff, UK.
Lawrence S WilkinsonBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Pscyhology, Cardiff University, Cardiff, UK.
Lora K HeislerRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Anthony R IslesBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Pscyhology, Cardiff University, Cardiff, UK. IslesAR1@cardiff.ac.uk.
Cardiff University · GBUniversity of Aberdeen · GBUniversity of Cambridge · GBUniversity of Edinburgh · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J016756/1Medical Research Council G0801418Medical Research Council G9723500Wellcome Trust WT081713Wellcome Trust WT098012
6 · The paper itself

Abstract

Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT

Indexed as

Alternative SplicingAnimalsAnorexiaAppetiteArcuate Nucleus of HypothalamusBase SequenceDisease Models, AnimalFeeding BehaviorMiceMutant ProteinsNeuronsPrader-Willi SyndromePro-OpiomelanocortinProto-Oncogene Proteins c-fosPyrazinesQuinoxalines8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a)quinoxalin-5(6H)-oneMutant ProteinsPro-OpiomelanocortinProto-Oncogene Proteins c-fosPyrazinesQuinoxalinesReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsAlternate splicingFeedingPrader-Willi syndromeSerotonin 2C recptorSnord115

Identifiers

PMID27931246
PMCPMC5144496
OpenAlexW2559762809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.