ArticleBMC neurology2016
Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study.
Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The association between H. pylori infection and cognitive deterioration: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Review
- Blood biomarkers and breed genetics of aging in pet dogs.bioRxiv : the preprint server for biology · 2026Article
- An integrated CSF-serum biomarker model for predicting clinical progression in Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Diagnostic work-up in periprosthetic joint infections of the knee: can the albumin-to-globulin ratio be a screening tool?Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Article
- The associations between the FAGR and all-cause and cardiovascular mortality in patients with STEMI.Scientific reports · 2025Article
- Predictive value of circulating inflammatory biomarkers for early-onset post-stroke cognitive impairment: a prospective cohort study.Frontiers in neurology · 2025Article
- Non-linear relationship of serum albumin-to-globulin ratio and cognitive function in American older people: a cross-sectional national health and nutrition examination survey 2011-2014 (NHANES) study.Frontiers in public health · 2024Article
- Association of serum albumin to globulin ratio with outcomes in acute ischemic stroke.CNS neuroscience & therapeutics · 2023Article
- Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients.BMC cardiovascular disorders · 2023Article
- Association between serum globulin and cognitive impairment in older American adults.Frontiers in public health · 2023Article
- Focusing onFrontiers in cellular and infection microbiology · 2023Review
- Albumin to globulin ratio was associated with in-stent restenosis and revascularization events after percutaneous coronary intervention.Clinical and translational science · 2022Article
- Associations of Serum Liver Function Markers With Brain Structure, Function, and Perfusion in Healthy Young Adults.Frontiers in neurology · 2021Article
- Cognitive impairment is associated with mitochondrial dysfunction in peripheral blood mononuclear cells of elderly population.Scientific reports · 2020Article
- Methamphetamine-Induced Cognitive Deficits and Psychiatric Symptoms Are Associated with Serum Markers of Liver Damage.Neurotoxicity research · 2020Article
- High Dose of Intravenous Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells (CLV-100) Infusion Displays Better Immunomodulatory Effect among Healthy Volunteers: A Phase 1 Clinical Study.Stem cells international · 2020Article
- Measuring proteins in HChemical science · 2019Article
- Systemic Inflammation Is Associated With Longitudinal Changes in Cognitive Performance Among Urban Adults.Frontiers in aging neuroscience · 2018Article
- Cannabidiol-enriched cannabis extraction product in Parkinson's disease: A randomized, double-blind, and placebo-controlled trial in Buriram Hospital.Journal of neurosciences in rural practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definitive candidate causes have been identified. The present study evaluated whether certain serum parameters predict CD.
methodsA total of 151 participants were assessed for CD using the Mini-Mental State Examination (MMSE), and 34 participants were identified as showing CD.
resultsAmong CD predictive risk factors, Helicobacter pylori seropositivity was significantly predictive of CD risk, more so than classical risk factors, including white matter lesions and arterial stiffness [adjusted odds ratio (OR) = 4.786, 95% confidence interval (CI) = 1.710-13.39]. A multivariate analysis indicated that the albumin to globulin (A/G) ratio was the only factor that significantly lowered CD risk (OR = 0.092, 95% CI = 0.010-0.887). A/G ratio also was positively correlated with MMSE scores and negatively correlated with disruption of homeostatic factors (i.e., non-high-density lipoprotein, hemoglobin A1c, and high-sensitive C-reactive protein).
conclusionsThe current study results suggest that the A/G ratio is related to cognitive decline and may reflect homeostatic alterations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.