Evidence map›Paper›PMID 27931146›Full record

ArticleJournal of neurotrauma2017

D-Cycloserine Restores Experience-Dependent Neuroplasticity after Traumatic Brain Injury in the Developing Rat Brain.

Naomi S Sta Maria, Maxine L Reger, Yan Cai, Mary Anne T Baquing, Floyd Buen, Aditya Ponnaluri, David A Hovda, Neil G Harris, Christopher C Giza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  13. Depression following traumatic brain injury in mice is associated with down-regulation of hippocampal astrocyte glutamate transporters by thrombin.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
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  16. Quantification of Biological Responses as Predictors of Cognitive Outcome after Developmental TBI.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Naomi S Sta Maria1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
Maxine L Reger1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
Yan Cai1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
Mary Anne T Baquing1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
Floyd Buen1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
Aditya Ponnaluri1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
David A Hovda1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
Neil G Harris1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
Christopher C Giza1 Department of Neurosurgery, UCLA Brain Injury Research Center , Los Angeles, California.
Brain Injury Association of America · USUCLA Medical Center · US

Funding

Using glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8M
A mechanism for stunted map plasticity after TBIR01NS091222 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARRIS, NEIL · 2015 to 2019
$1.7M
Restoration of plasticity after pediatric traumatic brain injuryK02NS057420 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GIZA, CHRISTOPHER C · 2007 to 2009
$533k
NINDS NIH HHS K02 NS057420NINDS NIH HHS R01 NS027544NINDS NIH HHS R01 NS091222
6 · The paper itself

Abstract

Traumatic brain injury (TBI) in children can cause persisting cognitive and behavioral dysfunction, and inevitably raises concerns about lost potential in these injured youth. Lateral fluid percussion injury (FPI) in weanling rats pathologically affects hippocampal N-methyl-d-aspartate receptor (NMDAR)- and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated glutamatergic neurotransmission subacutely within the first post-injury week. FPI to weanling rats has also been shown to impair enriched-environment (EE) induced enhancement of Morris water maze (MWM) learning and memory in adulthood. Recently, improved outcomes can be achieved using agents that enhance NMDAR function. We hypothesized that administering D-cycloserine (DCS), an NMDAR co-agonist, every 12 h (i.p.) would restore subacute glutamatergic neurotransmission and reinstate experience-dependent plasticity. Postnatal day 19 (P19) rats received either a sham or FPI. On post-injury day (PID) 1-3, animals were randomized to saline (Sal) or DCS. Firstly, immunoblotting of hippocampal NMDAR and AMPAR proteins were measured on PID4. Second, PID4 novel object recognition, an NMDAR- and hippocampal- mediated working memory task, was assessed. Third, P19 rats were placed in an EE (17 days), and MWM performance was measured, starting on PID30. On PID4, DCS restored reduced NR2A and increased GluR2 by 54%, and also restored diminished recognition memory in FPI pups. EE significantly improved MWM performance in shams, regardless of treatment. In contrast, FPI-EE-Sal animals only performed to the level of standard housed animals, whereas FPI-EE-DCS animals were comparable with sham-EE counterparts. This study shows that NMDAR agonist use during reduced glutamatergic transmission after developmental TBI can reinstate early molecular and behavioral responses that subsequently manifest in experience-dependent plasticity and rescued potential.

Indexed as

AnimalsBrain Injuries, TraumaticCombined Modality TherapyCycloserineDisease Models, AnimalEnvironmentExcitatory Amino Acid AgonistsMaleNeurological RehabilitationNeuronal PlasticityRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateCycloserineExcitatory Amino Acid AgonistsReceptors, AMPAReceptors, N-Methyl-D-Aspartatebehavioral assessmentslearning and memoryneuroplasticityreceptorsTBI

Identifiers

PMID27931146
PMCPMC5397224
OpenAlexW2559848308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.