ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2017
The Association of Vitamin D Status and Vitamin D Replacement Therapy with Glycemic Control, Serum Uric Acid Levels, and Microalbuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2020Pooled it
- Allopurinol has no effect on calcitriol or other CKD-MBD biomarkers: a randomized double-blind study.Journal of the Endocrine Society · 2026Article
- Association between 25 hydroxyvitamin D and serum uric acid level in the Chinese general population: a cross-sectional study.BMC endocrine disorders · 2024Article
- Article
- Serum 25-hydroxyvitamin D might be negatively associated with hyperuricemia in U.S. adults: an analysis of the National Health and Nutrition Examination Survey 2007-2014.Journal of endocrinological investigation · 2022Article
- Cystatin C, Vitamin D and Thyroid Function Test Profile in Chronic Kidney Disease Patients.Diseases (Basel, Switzerland) · 2021Article
- Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Review
- Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study.BMC endocrine disorders · 2020Observational
- Lower serum 25-hydroxyvitamin D levels are associated with impaired glomerular filtration rate in type 2 diabetes patients.Therapeutic advances in endocrinology and metabolism · 2020Article
- Urine albumin and serum uric acid are important determinants of serum 25 hydroxyvitamin D level in pre-dialysis chronic kidney disease patients.Renal failure · 2019Article
- Type 2 Diabetes Mellitus, Insulin Resistance, and Vitamin D.Current diabetes reports · 2019Review
- Role of Vitamin D Status in Diabetic Patients with Renal Disease.Medicina (Kaunas, Lithuania) · 2019Review
- Vitamin D deficiency and glycemic control among patients with type 2 diabetes mellitus in Jazan City, Saudi Arabia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Urinary Uromodulin/Creatinine Ratio as a Potential Clinical Biomarker for Chronic Kidney Disease Patients with Gout: A Pilot Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the relationship of vitamin D status and vitamin D replacement therapy with glycemic control, serum uric acid (SUA) levels, and microalbuminuria (MAU) in patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD). Subjectsand Methods: A total of 1,463 patients with T2DM and CKD (aged 14-88 years), 927 females and 536 males, were included in this study. The serum data of 25-hydroxyvitamin D, i.e., 25(OH)D, level, SUA, hemoglobin (Hb)A1c, creatinine, estimated glomerular filtration rate, and urine albumin-to-creatinine ratio (UACR) were obtained from the medical records. The Mann-Whitney U test, the χ2 test, the Mantel-Haenszel test, and linear regression models were used for data analysis.
resultsVitamin D deficiency and insufficiency were evident in 770 (52.0%) and 357 (24.0%) patients, respectively. Median HbA1c levels (7.3 [IQR 3.9] vs. 6.5 [IQR 2.3]%; p < 0.01) were significantly higher in patients deficient in vitamin D than in those with a normal vitamin D status. A significantly low level of vitamin D was noted with a high UACR (β -0.01; 95% CI -0.01 to -0.001; p = 0.017) and HbA1c (β -1.1; 95% CI -1.6 to -0.6; p < 0.001), but with low levels of SUA (β 1.3; 95% CI 0.5-2.2; p = 0.002). Vitamin D replacement was associated with a significantly low level of HbA1c (7.4 [2.7] vs. 6.7 [1.9]%; p < 0.001].
conclusionIn this study, there was a high prevalence of hypovitaminosis D among T2DM patients with CKD, with a higher UACR, higher HbA1c, and lower SUA being noted as playing a role in predicting a decrease in vitamin D levels and potential benefits of vitamin D replacement therapy on glycemic control in T2DM management.
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