Evidence map›Paper›PMID 27930937›Full record

ReviewCurrent opinion in neurobiology2017

Advances in myelinating glial cell development.

Amy L Herbert, Kelly R Monk

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Amy L HerbertDepartment of Developmental Biology, Washington University School of Medicine, 660 South Euclid Ave., Saint Louis, MO 63110, USA.
Kelly R MonkDepartment of Developmental Biology, Washington University School of Medicine, 660 South Euclid Ave., Saint Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 South Euclid Ave., Saint Louis, MO 63110, USA. Electronic address: monkk@wustl.edu.

Funding

MOLECULAR AND GENETIC ANALYSIS OF GPR126 IN PERIPHERAL NERVE.R01NS079445 · NINDS · WASHINGTON UNIVERSITY · PI MONK, KELLY R · 2012 to 2020
$3.1M
Chemical and genetic screens for modulators of nervous system development and myelinationR01HD080601 · NICHD · WASHINGTON UNIVERSITY · PI MONK, KELLY R · 2014 to 2018
$1.6M
Control of myelinating glial cell development by actr10F31NS096814 · NINDS · WASHINGTON UNIVERSITY · PI HERBERT, AMY · 2016 to 2017
$61k
NICHD NIH HHS R01 HD080601NINDS NIH HHS F31 NS096814NINDS NIH HHS R01 NS079445
6 · The paper itself

Abstract

In the vertebrate nervous system, the fast conduction of action potentials is potentiated by the myelin sheath, a multi-lamellar, lipid-rich structure that also provides vital trophic and metabolic support to axons. Myelin is elaborated by the plasma membrane of specialized glial cells, oligodendrocytes in the central nervous system (CNS) and Schwann cells (SCs) in the peripheral nervous system (PNS). The diseases that result from damage to myelin or glia, including multiple sclerosis and Charcot-Marie-Tooth disease, underscore the importance of these cells for human health. Therefore, an understanding of glial development and myelination is crucial in addressing the etiology of demyelinating diseases and developing patient therapies. In this review, we discuss new insights into the roles of mechanotransduction and cytoskeletal rearrangements as well as activity dependent myelination and axonal maintenance by glia. Together, these discoveries advance our knowledge of myelin and glia in nervous system health and plasticity throughout life.

Indexed as

AxonsHumansMechanotransduction, CellularNeurogliaNeurologyPeripheral Nervous System

Identifiers

PMID27930937
PMCPMC5316316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.